蛋白质硝基化与临床疾病  

Protein Tyrosine Nitration and Related Disease

作　　者：何旺青 谭梓雅 陈钰 周敏 常乐 姜淼 姜志胜[2] HE Wangqing;TAN Ziya;CHEN Yu;ZHOU Min;CHANG Le;JIANG Miao;JIANG Zhisheng(Hengyang Medical School,University of South China,Hunan Hengyang 421001;Institute of Cardiovascular Disease,Key Laboratory for Arteriosclerology of Hunan Province,Post-Doctoral Mobile Stations for Basic Medicine,University of South China,Hunan Hengyang 421001;Department of Bioinformatics and Medical Big Data Research,University of South China,Hunan Hengyang 421001)

机构地区：[1]南华大学衡阳医学院,湖南衡阳421001 [2]南华大学心血管疾病研究所,南华大学动脉硬化学湖南省重点实验室,南华大学动脉硬化性疾病湖南省国际科技合作创新基地,基础医学博士后流动站,湖南衡阳421001 [3]南华大学生物信息与医学大数据教研室,湖南衡阳421001

出　　处：《生物化工》2021年第5期138-141,共4页Biological Chemical Engineering

基　　金：湖南省自然科学基金(2018JJ3430);中国博士后科学基金(2018M632974);“生物流变科学与技术”教育部重点实验室开放基金(CQKLBST-2018-015);南华大学大学生研究性学习和创新性实验计划项目(2018XJXZ162)。

摘　　要：多种疾病的发生发展伴随着活性氧(ROS)或活性氮(RNS)的异常升高,如恶性肿瘤、缺血再灌注损伤以及各种炎症性疾病与神经退行性疾病等。在这些病理过程中,体内产生高浓度的超氧阴离子(O_(2)^(-))与NO可以发生反应,生成氧化能力更强的过氧亚硝酸盐(ONOO-),从而使蛋白质上的酪氨酸残基发生硝基化修饰,生成3-硝基酪氨酸(3-NT)。硝基化修饰蛋白质的结构与功能可能发生变化,进而导致线粒体、DNA损伤以及细胞凋亡或坏死,与疾病的进展密切相关。本文对蛋白质硝基化修饰与部分临床疾病的关系进行简要综述,为进一步研究3-NT的临床应用提供基础。The expression of reactive oxygen/nitrogen species(ROS/RNS)elevated during the progressive period of varies disease including cancer,ischemia reperfusion injury and some inflammatory disease or neurodegenerative disease,et al.During the pathophysiologic process,excessive produced O_(2)^(-)and NO could react to form ONOO-,a stronger oxidative molecule,which induce the modification of tyrosine to form 3-nitro tyrosine.After protein nitration,the structure and function of proteins may be changed to induce the mitochondrial and DNA injury and further cell apoptosis and necroptosis,which facilitating the disease progression.Here we reviewed the relationship between protein tyrosine nitration and related disease,which may provide foundations for further clinical studies.

关 键 词：蛋白质硝基化 临床疾病 活性氧 活性氮 

分 类 号：R363[医药卫生—病理学]