血清缺血修饰白蛋白及单核细胞趋化蛋白-1水平与急性脑梗死溶栓后恢复期神经功能恢复的相关性  

Correlations between levels of serum ischemia modified albumin,monocyte chemoattractant protein-1 and neurological function recovery during convalescence in patients with acute cerebral infarction after thrombolysis

作　　者：郭婷婷 杜华平 邱卓胤 吴燕华 GUO Tingting;DU Huaping;QIU Zhuoyin;WU Yanhua(Department of Neurology,Suzhou City Ninth People′s Hospital in Jiangsu Province,Suzhou,Jiangsu,215000)

机构地区：[1]江苏省苏州市第九人民医院神经内科,江苏苏州215000

出　　处：《实用临床医药杂志》2021年第17期48-51,56,共5页Journal of Clinical Medicine in Practice

基　　金：江苏省苏州市科技发展计划医疗卫生应用基础研究项目(SYSD2020044)。

摘　　要：目的分析血清缺血修饰白蛋白(IMA)、单核细胞趋化蛋白-1(MCP-1)水平与急性脑梗死(ACI)溶栓后恢复期神经功能恢复的关系。方法将40例ACI溶栓后恢复期神经功能恢复不良患者和40例神经功能恢复良好患者分别设为恢复不良组和恢复良好组。收集2组实验室检查资料、基线资料,分析血清IMA、MCP-1水平与ACI溶栓后恢复期神经功能恢复的关系。结果恢复不良组血清IMA、MCP-1水平高于恢复良好组,差异有统计学意义(P<0.05)。ACI患者血清IMA水平与MCP-1水平呈显著正相关(r=0.580,P<0.001),血清IMA、MCP-1水平过表达与ACI溶栓后恢复期神经功能恢复不良有关(OR>1,P<0.05)。血清IMA、MCP-1水平单独及联合预测ACI溶栓后恢复期神经功能恢复不良风险的曲线下面积(AUC)均>0.80。结论ACI溶栓后恢复期患者神经功能恢复不良可能与IMA、MCP-1的过表达有关。Objective To analyze the correlations between levels of serum ischemia modified albumin(IMA),monocyte chemoattractant protein-1(MCP-1)and neurological function recovery during convalescence in patients with acute cerebral infarction(ACI)after thrombolysis.Methods A total of 40 ACI patients with poor neurological function and 40 ACI patients with good neurological function during convalescence after thrombolysis were selected as poor recovery group and good recovery group.The laboratory examination data and baseline data of the two groups were collected,and the correlations between the levels of serum IMA,MCP-1 and the neurological function recovery during convalescence after ACI thrombolysis were analyzed.Results The levels of serum IMA and MCP-1 in the poor recovery group were significantly higher than those in the good recovery group(P<0.05).There was a positive correlation between serum IMA level and MCP-1 level in ACI patients(r=0.580,P<0.001),and the over-expressions of serum IMA and MCP-1 levels were associated with poor neurological function recovery during convalescence after ACI thrombolysis(OR>1,P<0.05).The area under curve(AUC)of serum IMA and MCP-1 levels alone and their combination to predict the risk of poor neurological function recovery during convalescence in patients with ACI after thrombolysis were greater than 0.80.Conclusion The over-expression of IMA and MCP-1 may be related to the poor neurological function recovery during convalescence in patients with ACI after thrombolysis.

关 键 词：急性脑梗死 溶栓治疗 神经功能 缺血修饰白蛋白 单核细胞趋化蛋白-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]