口咽部人乳头瘤病毒感染检测方法的研究进展  

Progress in detection of oropharyngeal human papillomavirus infection

作　　者：周潜 尹跃平 ZHOU Qian;YIN Yueping(Hospital of Dermatology of Peking Union Medical College of Chinese Academy of Medical Sciences,Nanjing,Jiangsu,210042;Center for Sexually Transmitted Disease Control of Chinese Centers for Disease Control and Prevention,Nanjing,Jiangsu,210042)

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院,江苏南京210042 [2]中国疾病预防控制中心性病控制中心,江苏南京210042

出　　处：《实用临床医药杂志》2021年第16期125-128,132,共5页Journal of Clinical Medicine in Practice

基　　金：国家级“艾滋病和病毒性肝炎等重大传染病”科技重大专项(2018ZX10101001-004-003)。

摘　　要：人乳头瘤病毒(HPV)是一种仅感染人类的双链DNA病毒,口咽部HPV感染可引起口腔潜在恶性疾病与头颈部鳞状细胞癌等不良后果,口咽部HPV感染的检测是早期诊断与治疗的关键。近年来,以核酸检测与免疫组化(IHC)作为检测HPV的主流方法,其他多种替代方法也得到了迅速发展。本文综述了口咽部HPV感染的不良后果与检测方法的研究进展,以期为临床应用提供参考依据。Human papillomavirus(HPV)is a double-stranded DNA virus that only infects humans.Oropharyngeal HPV infection can cause potential oral malignant diseases as well as head and neck squamous cell carcinoma and other adverse consequences.Detection of oropharyngeal HPV infection is the key to early diagnosis and treatment.In recent years,nucleic acid detection and immunohistochemistry(IHC)are the mainstream method for the HPV detection,and many alternative methods have also been rapidly developed.This article reviewed the research progress of adverse effects and detection methods of oropharyngeal HPV infection,so as to provide reference for clinical application.

关 键 词：人乳头瘤病毒 头颈部鳞状细胞癌 检测方法 口咽部 

分 类 号：R739.6[医药卫生—肿瘤] R373.9[医药卫生—临床医学]