富血小板纤维蛋白牙髓血运重建术联合二联抗菌药物糊剂治疗年轻恒牙牙髓坏死的效果  

Effects of Pulp Revascularization with Platelet-Rich Fibrin plus Double Antibiotic Paste on Treatment of Young Permanent Teeth with Pulp Necrosis

作　　者：杨柳青[1] 刘会林 YANG Liu-qing;LIU Hui-lin(Department of Stomatology,Zhoukou Central Hospital,Zhoukou 466000,China;Department of Stomatology,Kaifeng Central Hospital,Kaifeng 475000,China)

机构地区：[1]周口市中心医院口腔科,周口466000 [2]开封市中心医院口腔科,开封475000

出　　处：《中国合理用药探索》2021年第10期77-80,共4页Chinese Journal of Rational Drug Use

摘　　要：目的:探究富血小板纤维蛋白(PRF)牙髓血运重建术联合二联抗菌药物糊剂(DAP)在年轻恒牙牙髓坏死治疗中的应用效果。方法:选取本院2018年9月~2019年9月收治的年轻恒牙牙髓坏死患者102例作为研究对象,采用随机数字表法分为观察组(PRF牙髓血运重建术+DAP治疗)与对照组(常规牙髓血运重建术+DAP治疗),每组51例。根据患者入院时间列出1~102个号码,利用特制的摇码器(或电子计算机),自动逐个摇出两组号码以进行分组,探讨实施不同治疗对治疗效果的影响。结果:观察组总有效率(94.12%)高于对照组(80.39%,P<0.05),且观察组并发症发生率(7.84%)低于对照组(19.61%,P<0.05);观察组闭合时长、力横向偏移量低于对照组,但咬合力、咀嚼效率高于对照组(P<0.05);治疗前两组牙根长度、根管壁厚无统计学差异(P>0.05),治疗后两组牙根长度无统计学差异(P>0.05),但根管壁厚观察组高于对照组(P<0.05);治疗前两组视觉模拟评分(VAS)和生活质量评分(QOL)对比无统计学差异(P>0.05),治疗后观察组VAS评分低于对照组,但QOL评分高于对照组(P<0.05)。结论:对年轻恒牙牙髓坏死患者采取PRF牙髓血运重建术+DAP治疗后,能够快速减轻患者疼痛,促进病情快速稳定、牙齿功能快速恢复,同时防止并发症产生、促进根管壁生长,此方法值得临床应用推广。Objective:To explore the effects of pulp revascularization with platelet-rich fibrin(PRF)plus double antibiotic paste(DAP)on treatment of young permanent teeth with pulp necrosis.Methods:A total of 102 patients with young permanent teeth of pulp necrosis treated from September 2018 to September 2019 in our hospital were selected as research subjects.According to random number table,patients were assigned to observation group(pulp revascularization with PRF and DAP)and control group(conventional pulp revascularization and DAP),51 cases in each group.Listed 1 to 102 numbers based on the time of admission and used a special shaker(or computer)to automatically shake out the numbers of the two groups and divide them into groups to explore the effects of different treatments.Results:Total effective rate in the observation group(94.12%)was significantly higher than that in control group(80.39%,P<0.05);and the complication rate in the observation group(7.84%)was significantly lower than that in control group(19.61%,P<0.05);compared with control group,occlusion time and lateral deviations in the observation group were reduced while occlusal force and chewing efficiency were increased(P<0.05);before treatment,root length and root canal thickness between two groups were not significantly different(P>0.05);after treatment,root length between two groups was not significantly different(P>0.05);however,root canal thickness in the observation group was higher than that in control group(P<0.05);before treatment,VAS(visual analogue scale)and QOL(quality of life)scores between two groups were not significantly different(P>0.05);after treatment,VAS scores in the observation group were lower than those in control group;but QOL scores were higher than those in control group(P<0.05).Conclusion:The pulp revascularization with PRF and DAP can quickly relieve patient s pain,stabilize the illness state,promote the teeth function recovery and root canal growth,and avoid the complications.

关 键 词：牙髓坏死 恒牙重建术 富血小板纤维蛋白 根管 二联抗菌药物糊剂 

分 类 号：R782[医药卫生—口腔医学] R969[医药卫生—临床医学]