急性髓系白血病患儿血清25羟维生素D_(3)含量与疗效及预后的相关性  

The correlation between serum 25-hydroxyvitamin D_(3) level and efficacy,prognosis in children with acute myeloid leukemia

作　　者：马慧平[1] 王立华[1] 童琳琳 段杨 赵志勇[1] MA Huiping;WANG Lihua;TONG Linlin;DUAN Yang;ZHAO Zhiyong(Handan Central Hospital,Hebei Handan 056000,China)

机构地区：[1]邯郸市中心医院,河北邯郸056000

出　　处：《现代肿瘤医学》2021年第22期4006-4009,共4页Journal of Modern Oncology

基　　金：河北省医学科学研究课题计划(编号:20191852)。

摘　　要：目的:研究急性髓系白血病(acute myeloid leukemia,AML)患儿血清25羟维生素D_(3)(25-OH-D_(3))含量与疗效及预后的相关性。方法:选择2014年6月至2016年12月期间在我院首次诊断为AML患儿作为AML组、体检的健康儿童作为对照组。检测对照组的血清25-OH-D_(3)含量及AML组化疗前、首疗程化疗后3天、首疗程化疗结束时的血清25-OH-D_(3)含量,评价AML患儿首疗程缓解情况,随访AML患儿的总生存期(OS)。结果:AML组患儿的血清25-OH-D_(3)含量明显低于对照组(P<0.05),且外周血白细胞(WBC)≥50×109/L、危险度分级高危、骨髓Ki-67阳性患儿的血清25-OH-D_(3)含量明显低于WBC<50×109/L、中低危、Ki-67阴性患儿(P<0.05);化疗前、首疗程化疗后3天、首疗程化疗结束时,AML组中首疗程缓解患儿的血清25-OH-D_(3)含量明显高于首疗程未缓解患儿(P<0.05);AML组中化疗前、首疗程化疗后3天、首疗程化疗结束时25-OH-D_(3)缺乏患儿的OS均短于25-OH-D_(3)正常患儿(P<0.05)。结论:25-OH-D_(3)缺乏与AML发生、病情发展、首疗程缓解及生存期缩短有关。Objective:To study the correlation between serum 25-hydroxyvitamin D_(3)(25-OH-D_(3))level and efficacy,prognosis in children with acute myeloid leukemia(AML).Methods:Children with AML diagnosed for the first time in our hospital from June 2014 to December 2016 were selected as AML group,and healthy children with physical examination as the control group.Serum 25-OH-D_(3) level of control group and serum 25-OH-D_(3) levels of AML group before chemotherapy,3 days after the first course of chemotherapy,at the end of the first course of chemotherapy were measured.The first course remission of children in AML group was evaluated.The total survival(OS)of AML children was followed up.Results:The serum 25-OH-D_(3) level of AML group was significantly lower than that in control group(P<0.05).The serum 25-OH-D_(3) level in peripheral blood white blood cell(WBC)≥50×109/L,high-risk grading,bone marrow Ki-67 positive children was significantly lower than that in WBC<50×109/L,middle-low-risk and Ki-67 negative children(P<0.05).Before chemotherapy,at 3 days after the first course of chemotherapy and at the end of the first course,the serum 25-OH-D_(3) level of the first course remission in AML group was significantly higher than those with the first course non-remission(P<0.05).In AML group,the OS of children with 25-OH-D_(3) deficiency before chemotherapy,3 days after the first course of chemotherapy and at the end of the first course were shorter than those with normal 25-OH-D_(3)(P<0.05).Conclusion:25-OH-D_(3) deficiency is associated with occurrence of AML,development of disease,the first course remission and shortened survival.

关 键 词：急性髓系白血病 25羟维生素D_(3) 首疗程缓解 生存 

分 类 号：R733.71[医药卫生—肿瘤]