GC-MS测定西洋参中的腐霉利  

Determination of Procymidone in Panacis Quinquefolii Radix by GC-MS

作　　者：朱日然[1] 牛水蛟 刘莹 张先勤 李启艳 林钰镓 ZHU Ri-ran;NIU Shui-jiao;LIU Ying;ZHANG Xian-qin;LI Qi-yan;LIN Yu-jia(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250012,China;NMPA Key Laboratory for Quality Evaluation of Cosmetic Raw Materials,Shandong Institute for Food and Drug Control,Jinan 250101,China;Jinan Lixia District Health and Family Planning Supervision Institute,Jinan 250021,,China)

机构地区：[1]山东中医药大学附属医院,山东济南250012 [2]山东省食品药品检验研究院/国家药品监督管理局化妆品原料质量控制重点实验室,山东济南250101 [3]济南市历下区卫生和计划生育监督所,山东济南250021

出　　处：《食品与药品》2021年第5期397-401,共5页Food and Drug

基　　金：国家食品药品监督管理总局-保健食品原料目录研究专项课题(编号:ZBW-2017-BJSP-11)。

摘　　要：目的建立GC-MS测定西洋参中腐霉利的方法。方法西洋参药材经提取并用QuEChERS法净化,进入气相色谱串联质谱仪,经外标曲线法定量,测定药材中腐霉利的含量。结果在0.5~10μg/ml范围内,腐霉利呈现良好的线性关系(r>0.99),检出限为0.003 mg/kg,回收率90.7%~92.6%,相对标准偏差(RSD)小于6.3%。结论所建方法灵敏、准确,适用性强,可以快速、准确地分析西洋参中的腐霉利含量。Objective To establish a GC-MS method for the determination of procymidone in Panacis quinquefolii radix.Methods After Panacis quinquefolii radix medicinal materials were extracted and purified by QuEChERS,the content of procymidone in Panacis quinquefolii radix medicinal materials was determined by GC-MS and quantified by external standard curve method.Results Procymidone had a good linear relationship in the range of 0.5-10μg/ml(r>0.99).The limit of detection was 0.003 mg/kg and the recovery was 90.65%-92.63%,with RSDs no more than 6.3%.Conclusion This method is rapid,accurate and sensitive,and can be used for the determination of procymidone in Panacis quinquefolii radix.

关 键 词：西洋参 腐霉利 气相色谱-质谱联用法(GC-MS) QuEChERS法 

分 类 号：TS207.53[轻工技术与工程—食品科学]