精神分裂症患者血清D-乳酸、二胺氧化酶、内毒素的变化  

Changes of serum diamine oxidase,D-lactic acid and endotoxin in patients with schizophrenia

作　　者：金伟峰[1] 李萍[1] 陈姝子 孙佳琪[1] 方伟[1] 李丹[1] 朱丽萍[1] 朱莉莉[1] 林萍[1] JIN Weifeng;LI Ping;CHEN Shuzi;SUN Jiaqi;FANG Wei;LI Dan;ZHU Liping;ZHU Lili;LIN Ping(Department of Clinical Laboratory,Shanghai Mental Health Center,Shanghai 200030,China)

机构地区：[1]上海市精神卫生中心检验科,上海200030

出　　处：《检验医学》2021年第10期1039-1041,共3页Laboratory Medicine

基　　金：上海市精神卫生中心院级课题(2018-YJ-15)。

摘　　要：目的探讨血清二胺氧化酶、D-乳酸及内毒素在精神分裂症患者肠道屏障损伤评估中的作用。方法选取精神分裂症患者296例(精神分裂症组)、体检健康者99名(正常对照组),检测血清二胺氧化酶、D-乳酸及内毒素水平。将296例精神分裂症患者按年龄(≤51岁、>51岁)和性别分别分组。结果精神分裂症组血清二胺氧化酶、D-乳酸及内毒素水平均高于正常对照组(P<0.05)。精神分裂症组≤51岁者与>51岁者之间、男性与女性之间血清二胺氧化酶、D-乳酸及内毒素水平差异均无统计学意义(P>0.05)。结论血清二胺氧化酶、D-乳酸和内毒素可作为评估精神分裂症患者肠道屏障功能的指标。Objective To investigate the roles of serum diamine oxidase,D-lactic acid and endotoxin in the assessment of intestinal barrier injury in patients with schizophrenia. Methods A total of 296 schizophrenia patients and 99 healthy subjects were enrolled,and serum diamine oxidase,D-lactic acid and endotoxin levels were determined. The 296 schizophrenia patients were classified according to ages(≤51-year-old and >51-year-old groups) and sex. Results The levels of serum diamine oxidase,D-lactic acid and endotoxin in schizophrenia group were higher than those in healthy control group(P<0.05). There was no statistical significance in serum diamine oxidase,D-lactic acid and endotoxin between ≤51-year-old and >51-year-old groups and between males and females(P>0.05). Conclusions Serum diamine oxidase,D-lactic acid and endotoxin can be used to assess the intestinal barrier function in patients with schizophrenia.

关 键 词：二胺氧化酶 D-乳酸 细菌内毒素 精神分裂症 

分 类 号：Q554[生物学—生物化学]