鞘糖脂与肿瘤疾病相关性研究进展  

Research progress in the correlation between glycosphingolipids and tumor diseases

作　　者：金雪峰 杨广宇[1] JIN Xue-feng;YANG Guang-yu(State Key Laboratory of Microbial Metabolism,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China;Department of Pharmacy,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]上海交通大学生命科学技术学院/微生物代谢国家重点实验室,上海200240 [2]广西壮族自治区人民医院药学部,南宁530021

出　　处：《中国临床新医学》2021年第10期976-980,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金项目(编号:31670791)。

摘　　要：鞘糖脂作为存在于生命体细胞膜表面的双亲性糖脂分子,具有维持质膜稳定性、介导细胞识别黏附、调节信号转导等重要生物学功能。特异性的鞘糖脂被发现在众多的肿瘤疾病中呈异常表达并参与相关分子机制,与疾病发展进程密切相关,其作为肿瘤疾病诊断标志物以及免疫治疗的重要靶点被广泛研究。该文针对不同种类鞘糖脂与肿瘤疾病的相关性研究进展进行了综述。Glycosphingolipids,as amphiphilic glycolipids on the surface of cell membranes of living organisms,have important biological functions such as maintaining plasma membrane stability,mediating cell recognition and adhesion,regulating signal transduction and so on.Specific glycosphingolipids have been found to be abnormally expressed in many tumor diseases and participate in related molecular mechanisms.They are closely related to the development of diseases and are widely studied as diagnostic markers of tumor diseases and important targets of immunotherapy.In this paper,the research progress in the correlation between different kinds of glycoshingolipids and tumor diseases is reviewed.

关 键 词：鞘糖脂 肿瘤疾病 信号转导 生物标志物 

分 类 号：R730.2[医药卫生—肿瘤]