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作 者:张竹慧[1] 陈晴晴 撒楠[1] 马泰 汪梦 吴小珉 王鹏 韩海红 孙永[1] ZHANG Zhuhui;CHEN Qingqing;SA Nan;MA Tai;WANG Meng;WU Xiaomin;WANG Peng;HAN Haihong;SUN Yong(Anhui Provincial Center for Disease Control and Prevention,Anhui Hefei 230601,China;China National Center for Food Safety Risk Assessment,Beijing 100021,China)
机构地区:[1]安徽省疾病预防控制中心,安徽合肥230601 [2]国家食品安全风险评估中心,北京100021
出 处:《中国食品卫生杂志》2021年第5期536-541,共6页Chinese Journal of Food Hygiene
基 金:国家科技重大专项(2018ZX10733402-006、2018ZX10713003-002-005)。
摘 要:目的了解安徽省近年来沙门菌(Salmonella)的血清型分布及耐药特性,为本省沙门菌引起腹泻病的诊断和治疗提供科学依据。方法对2015—2020年来自安徽省16个地市食源性疾病主动监测腹泻病例中分离出的980株沙门菌进行血清分型,采用微量肉汤稀释法进行药物敏感性实验。结果980株沙门菌分为82种血清型,优势血清型为肠炎沙门菌[31.43%(308/980)]、鼠伤寒沙门菌[26.22%(257/980)]、阿贡纳沙门菌[7.35%(72/980)]、汤卜逊沙门菌[6.63%(65/980)]和伦敦沙门菌[3.37%(33/980)]。沙门菌对氨苄西林(AMP)、萘啶酸(NAL)、四环素(TET)、氨苄西林/舒巴坦(AMS)耐药率较高,分别为62.35%、47.96%、47.86%、43.16%;对AMP、AMS、NAL、头孢西丁(CFX)、阿奇霉素(AZM)耐药率呈现明显上升趋势(P<0.05)。沙门菌耐药性呈现区域性特点,皖北地区耐药情况较皖中、皖南更加严重。多重耐药率达40.41%,鼠伤寒沙门菌、伦敦沙门菌多重耐药严重。结论2015—2020年安徽省腹泻病人沙门菌血清型主要为肠炎沙门菌、鼠伤寒沙门菌、阿贡纳沙门菌、汤卜逊沙门菌和伦敦沙门菌。菌株耐药情况较严重,且对多数抗生素耐药率呈上升趋势,多重耐药水平较高。需密切关注并持续对本地区沙门菌的耐药情况进行监测。Objective The present study was undertaken to identify the serotypes and drug resistance profiles of Salmonella recovered from diarrheal patients in Anhui Province,and provide evidence for the diagnosis and treatment of foodborne diseases caused by Salmonella.Methods From 2015 to 2020,980 Salmonella were collected from 16 Centers for Disease Control and Prevention in Anhui Province.The strains were serotyped,and the drug susceptibility profile was studied by micro-broth dilution method.Results Nine hundred and eighty Salmonella included 82 serotypes with a predominance of Salmonella enteritidis 31.43%(308/980),Salmonella typhimurium 26.22%(257/980),Salmonella agona 7.35%(72/980),Salmonella thompson 6.63%(65/980)and Salmonella london 3.37%(33/980).The highest resistance were ampicillin(AMP),nalidixin(NAL),tetracycline(TET)and ampicillin/sulbactam(AMS),which were 62.35%,47.96%,47.86%,43.16%,respectively.The resistance rates to AMP,AMS,NAL,cefoxitin(CFX),and azithromycin(AZM)showed a significant upward trend(P<0.05).The drug resistance of Salmonella showed different features in different regions.It was worse in the north than the south and central Anhui Province.The multi-drug resistance rate reached 40.41%,and Salmonella typhimurium and Salmonella london were highly resistant to multiple drugs.Conclusion From 2015 to 2020,the predominant Salmonella serotypes of diarrheal patients in Anhui Province were Salmonella enteritidis,Salmonella typhimurium,Salmonella agona,Salmonella thompson and Salmonella london.Drug resistance was serious,and most resistance rate showed an increasing trend from 2015 to 2020.The multiple drug resistance was a serious problem.It is necessary to pay close attention to monitor the resistance of Salmonella in Anhui Province.
分 类 号:R155[医药卫生—营养与食品卫生学]
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