MCP-1和MIP-1α在牙龈炎和牙周炎患者体液中的表达水平及意义  

Expression of MCP-1and MIP-1αin body liquid from healthy individuals,gingivitis and periodontitis

作　　者：王仁兰[1] WANG Ren-lan(Department of Stomatolgy,Affiliated Hospital of Jilin Medical University,Jilin132011,China)

机构地区：[1]吉林医药学院附属医院口腔科,吉林吉林132011

出　　处：《中国实验诊断学》2021年第10期1476-1479,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的分析巨噬细胞炎性蛋白-1α(MIP-1α)和单核细胞趋化蛋白-1(MCP-1)在健康受试者、牙龈炎患者以及牙周炎患者龈沟液、唾液及外周血清的表达水平,评价MIP-1α、MCP-1在牙周炎病理进程中的意义。方法按标准纳入健康受试者(20人)、牙龈炎患者(20例)以及牙周炎患者(20例),分别记录其年龄、性别、探诊深度(PD)、菌斑指数(PI)、附着丧失(CAL)以及出血指数(BOP)。检测其唾液、龈沟液及外周血清中MIP-1α、MCP-1表达水平。结果各组受试者年龄分布、性别构成比间比较差异无统计学意义(P>0.05)。牙龈炎组各项临床指标高于健康组,牙周炎组高于牙龈炎组,差异有统计学意义(P<0.05)。牙周炎组龈沟液及唾液中MIP-1α和MCP-1浓度均高于其他组别(P<0.05)。牙龈炎组患者龈沟液MIP-1α、MCP-1以及唾液MIP-1α浓度均高于健康组(P<0.05)。各组间血清中检测结果比较差异无统计学意义(P>0.05)。结论局部组织内MIP-1α、MCP-1随着牙周炎症进展而升高,且与牙周炎各临床指标呈正相关。Objective To analysis the level of MIP-1α,MCP-1of body liquid from individuals with gingivitis,periodontitis,or healthy controls.Methods We record their age,gender,Probing depth(PD),Plaque index(PI),Clinical attachment level(CAL),Bleeding on probing(BOP),and detected their MIP-1α,MCP-1level in body liquid by ELISA.Results Periodontal index increased form healthy to periodontitis.In comparison with controls,individuals with gingivitis showed higher concentration of MIP-1α,MCP-1in GCF or MIP-1αin saliva.Individuals with periodontitis showed the highest level of MIP-1α,MCP-1in both GCF and saliva than all other groups.We did not find significant difference among the three groups in markers from blood sera.Conclusion MIP-1αand MCP-1increased their levels accompany with the development of periodontal inflammations.

关 键 词：MIP-1Α MCP-1 牙周炎 唾液 龈沟液 

分 类 号：R781.4[医药卫生—口腔医学]