TRPM7和GATA6蛋白在卵巢浆液性腺癌中的表达及意义  

Expressions and significance of TRPM7 and GATA6 protein in ovarian serous adenocarcinoma

作　　者：刘怡 奚卫 许鹏 谈宗国 薛佩佩 LIU Yi;XI Wei;XU Peng;TAN Zongguo;XUE Peipei(Chongqing Municipal Population and Family Planning Science and Technology Research Institute Key Lab of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing 400020,China;Chongqing University Three Gorges Hospital,Chongqing 404000,China)

机构地区：[1]重庆市人口和计划生育科学技术研究院/国家卫生计生委出生缺陷与生殖健康重点实验室,重庆400020 [2]重庆大学附属三峡医院,重庆404000

出　　处：《国际检验医学杂志》2021年第21期2596-2600,2605,共6页International Journal of Laboratory Medicine

基　　金：重庆市科研院所绩效激励引导专项项目(cstc2017jxjl130002)。

摘　　要：目的探讨卵巢浆液性腺癌中瞬时受体电位M7通道(TRPM7)蛋白和GATA结合蛋白6(GATA6)的表达水平及意义。方法选取2012年3月至2015年7月重庆大学附属三峡医院收治的卵巢浆液性腺癌患者79例为卵巢浆液性腺癌组,另选取同期因子宫肌瘤或子宫腺肌病行子宫及卵巢切除术的患者56例为对照组。采用免疫组织化学染色法检测组织中TRPM7和GATA6蛋白表达水平。对卵巢浆液性腺癌患者进行5年随访,Kaplan-Meier法绘制生存曲线,Cox回归模型进行预后影响因素分析。结果卵巢浆液性腺癌组织中TRPM7、GATA6蛋白高表达率均明显高于正常卵巢组织(P<0.05)。FIGO分期Ⅲ~Ⅳ期、病理分级高级别、有大网膜转移、有淋巴结转移、有远处转移的患者癌组织中TRPM7、GATA6蛋白高表达率均明显高于FIGO分期Ⅰ~Ⅱ期、病理分级低级别、无大网膜转移、无淋巴结转移、无远处转移的患者(P<0.05)。卵巢浆液性腺癌组织中TRPM7蛋白表达与GATA6蛋白表达呈正相关(r=0.427,P<0.05)。TRPM7、GATA6蛋白高表达组患者5年总生存率分别低于TRPM7、GATA6蛋白低表达组患者(P<0.05)。FIGO分期Ⅲ~Ⅳ期、有淋巴结转移、有远处转移、TRPM7蛋白高表达、GATA6蛋白高表达是卵巢浆液性腺癌患者不良预后的独立危险因素(P<0.05)。结论卵巢浆液性腺癌组织中TRPM7、GATA6蛋白表达上调,二者可作为生物标志物为临床评估卵巢浆液性腺癌患者预后提供一定帮助。Objective To investigate the expression levels and significance of transient receptor potential melastatin 7(TRPM7)and GATA binding protein 6(GATA6)in ovarian serous adenocarcinoma.Methods Seventy-nine patients with ovarian serous adenocarcinoma treated in Chongqing University Three Gorges Hospital from March 2012 to July 2015 were selected as the ovarian serous adenocarcinoma group,and contemporaneous 56 patients with hysterectomy and ovariectomy due to hysteromyoma or adenomyosis were selected as the control group.The expression levels of TRPM7 and GATA6 protein were detected by immunohistochemistry.The ovarian serous adenocarcinoma patients were followed up for 5 years,the survival curve was drawn by Kaplan Meier method,and the prognostic influencing factors were analyzed by Cox regression model.Results The high expression rates of TRPM7 and GATA6 proteins in ovarian serous adenocarcinoma were significantly higher than those in normal ovarian tissue(P<0.05).The high expression rates of TRPM7 and GATA6 proteins in the cancer tissues of the patients with the FIGO stageⅢ-Ⅳ,high pathological grade,omentum majus metastasis,lymph node metastasis and distant metastasis were significantly higher than those in the patients with the FIGO stageⅠ-Ⅱ,low pathological grade,no omentum majus metastasis,no lymph node metastasis and no distant metastasis(P<0.05).There was a positive correlation between TRPM7 and GATA6 protein expressions in ovarian serous adenocarcinoma tissue(r=0.427,P<0.05).The 5-year survival rate of the patients with high expressions of TRPM7 and GATA6 was significantly lower than that of the patients with low expressions of TRPM7 and GATA6(P<0.05).The FIGO stageⅢ-Ⅳstage,lymph node metastasis,distant metastasis,high expression of TRPM7 and high expression of GATA6 were the independent risk factors affecting the poor prognosis in the patients with ovarian serous adenocarcinoma(P<0.05).Conclusion The expressions of TRPM7 and GATA6 are up-regulated in ovarian serous adenocarcinoma tissue,and TRPM7

关 键 词：瞬时受体电位通道蛋白7 GATA结合蛋白6 卵巢浆液性腺癌 

分 类 号：R737.31[医药卫生—肿瘤]