cFos-ANAB:A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors  

作　　者：Fan Wang Wenjie Sun Lei Chang Kefang Sun Leying Hou Linna Qian Chaoyin Jin Jiandong Chen Jiali Pu Panmeng Ye Shuang Qiu Jianhong Luo Shumin Duan Baorong Zhang Zhihua Gao Xiaojun Hu 

机构地区：[1]Center for Neuroscience and Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [2]Medical Information Center,Zhejiang University School of Medicine,Hangzhou 310058,China [3]Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [4]Hangzhou Hikvision Digital Technology Co.,Ltd,Hangzhou 310053,China

出　　处：《Neuroscience Bulletin》2021年第10期1441-1453,共13页神经科学通报（英文版）

基　　金：by the National Natural Science Foundation of China(71974167 and 71573225).

摘　　要：cFos is one of the most widely-studied genes in the field of neuroscience.Currently,there is no systematic database focusing on cFos in neuroscience.We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice,comprising 398 brain nuclei and sub-nuclei,and five associated behaviors:pain,fear,feeding,aggression,and sexual behavior.Direct relationships among behaviors and nuclei(even cell types)under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications.Moreover,overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized,leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits.Using the analysis function of cFos-ANAB,multi-layered pictures of networks and their relationships can quickly be explored depending on users’purposes.These features provide a useful tool and good reference for early exploration in neuroscience.The cFos-ANAB database is available at www.cfos-db.net.

关 键 词：cFos expression Curated database Brain nucleus Behavior STIMULUS Visualization tools 

分 类 号：R741[医药卫生—神经病学与精神病学]