人巨细胞病毒感染与疣状胃炎病理特征及幽门螺旋杆菌的关系  

Research of the relationship between human cytomegalovirus infection and histopathological features in verrucous gastritis and Helicobacter pylori

作　　者：赵明星[1] 张雪丽[1] 阎艳[2] 朱玉侠[1] 孔祥云[1] 姜登鸽 ZHAO Mingxing;ZHANG Xueli;YAN Yan;ZHU Yuxia;KONG Xiangyun;JIANG Dengge(Department of Gastroenterology,Xi’an NO.1 Hospital,Xi’an 710002,China;Department of Pathology,Xi’an NO.1 Hospital,Xi’an 710002,China)

机构地区：[1]西安市第一医院消化内科,陕西西安710002 [2]西安市第一医院病理科,陕西西安710002

出　　处：《胃肠病学和肝病学杂志》2021年第10期1140-1143,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的检测疣状胃炎组织中人巨细胞病毒(HCMV)的表达,探讨其与疣状胃炎病理特征及幽门螺旋杆菌(H.pylori)的关系。方法选取就诊于西安市第一医院消化内科经内镜诊断为疣状胃炎患者80例(研究组)及慢性浅表性胃炎患者70例(对照组)为研究对象,采用免疫组化SP法对病理标本进行HCMV的检测并观察HCMV表达情况,并进一步将研究组根据H.pylori感染情况分为H.pylori阳性组和H.pylori阴性组,观察HCMV的表达情况及其病理特征。结果研究组组织中HCMV表达阳性率(35.0%)高于对照组HCMV表达阳性率(0)(P<0.05);研究组中H.pylori阳性组及H.pylori阴性组HCMV表达阳性率分别为71.0%、12.2%,差异有显著统计学意义;研究组HCMV+H.pylori+、HCMV+H.pylori-、HCMV-H.pylori+、HCMV-H.pylori-不同亚组间炎症活动程度及肠化率对比,差异有统计学意义(P<0.05),其中HCMV+H.pylori+组与非HCMV+H.pylori+组中-重度炎症活动发生率分别为77.3%、31.0%,肠化率分别为77.3%、12.1%,差异有统计学意义(P<0.05)。结论部分疣状胃炎组织中存在HCMV感染,疣状胃炎的发生可能有HCMV的参与,并且可能与H.pylori共同致病。Objective To detect the expression of human cytomegalovirus(HCMV)in gastric mucosa of verrucous gastritis and to explore its relationship with Helicobacter pylori(H.pylori)infection and pathological features.Methods 80 cases with verrucous gastritis as study group and 70 cases with chronic superficial gastritis as control group diagnosed by endoscopy in the Department of Gastroenterology,Xi’an NO.1 Hospital.These pathological samples were detected by immunohistochemistry SP method to observe the HCMV expression,and the study group was further divided into H.pylori positive group and H.pylori negative group according to H.pylori infection conditions,to observe the expression of HCMV and pathological features.Results The incidence of HCMV expression positive in study group was 35.0%,while the incidence of HCMV expression positive in control group was 0,the positive rate of HCMV expression in the study group was higher than that in the control group(P<0.05).The positive rates of HCMV expression in the H.pylori positive group and H.pylori negative group were 71.0%and 12.2%,respectively,the positive rate of HCMV in the H.pylori positive group was significantly higher than that in the H.pylori negative group(P<0.05).There were statistically significant differences in inflammatory activity and incidence of intestinal metaplasia among different subgroups of HCMV+H.pylori+,HCMV+H.pylori-,HCMV-H.pylori+,HCMV-H.pylori-in study group(P<0.05).The incidence of moderate to severe inflammatory activity in the HCMV+H.pylori+group and the non-HCMV+H.pylori+group were 77.3%and 31.0%,intestinal metaplasia were 77.3%and 12.1%,respectively,while the incidence of moderate to severe inflammatory activity and intestinal metaplasia in the HCMV+H.pylori+group were higher than those in the non-HCMV+H.pylori+group(P<0.05).Conclusion HCMV infection exists in some tissues of verrucous gastritis.The occurrence of verrucous gastritis may involve HCMV and may co-cause disease with H.pylori.

关 键 词：疣状胃炎 人巨细胞病毒 幽门螺旋杆菌 

分 类 号：R573.3[医药卫生—消化系统]