自身免疫性肝病患者血清LECT2的表达水平及临床意义  

Expression level and clinical significance of serum LECT2 in patients with autoimmune liver disease

作　　者：徐朝艳 刘维雪 卢宏凯[2] XU Zhaoyan;LIU Weixue;LU Hongkai(Department of Laboratory,Shuangqiao Hospital of Chaoyang District,Beijing 100024;Department of Blood Transfusion,China-Japan Friendship Hospital,China)

机构地区：[1]北京市朝阳区双桥医院检验科,北京100024 [2]中日友好医院输血科

出　　处：《胃肠病学和肝病学杂志》2021年第10期1157-1161,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的分析自身免疫性肝病患者血清白细胞衍生趋化因子2(LECT2)的表达水平及临床意义。方法选取北京市朝阳区双桥医院收治的自身免疫性肝病患者45例作为研究组,同期在门诊健康体检者45名作为对照组,采用酶联免疫吸附法检测所有入选对象血清LECT2表达水平,以比色法检测天门冬氨基酸氨基转移酶(AST)、谷丙转氨酶(ALT)、谷氨酰转移酶(GGT)水平,以全自动生化仪检测总胆红素(TBIL)、直接胆红素(DBIL)水平,以Pearson分析血清LECT2水平与血清AST、GGT、ALT、DBIL、TBIL水平的相关性。结果进展期患者血清LECT2、AST、ALT、DBIL、TBIL、GGT水平均高于缓解期患者和对照组(P均<0.05),缓解期患者与对照组上述指标比较,差异均无统计学意义(P均>0.05)。未愈组患者血清LECT2、AST、ALT、GGT、DBIL、TBIL水平均高于好转组和对照组(P均<0.05),好转组与对照组上述指标比较,差异均无统计学意义(P均>0.05)。Pearson相关分析结果显示,自身免疫性肝病患者血清LECT2水平与血清AST、GGT、ALT、DBIL、TBIL水平均呈正相关(r=0.360、0.491、0.431、0.316、0.452,P均<0.05)。结论自身免疫性肝病患者血清中LECT2呈高表达,其水平与血清AST、GGT、ALT、DBIL、TBIL水平均呈正相关,血清LECT2水平可能作为评估疾病严重程度的指标。Objective To analyze the expression level and clinical significance of serum leukocyte cell-derived chemotaxin 2(LECT2)in patients with autoimmune liver disease.Methods A total of 45 patients with autoimmune liver disease in the Shuangqiao Hospital of Chaoyang District were selected as study group,and 45 healthy people in the Department of Outpatient were selected as control group.The expression level of LECT2 in serum was detected by enzyme linked immunosorbent assay,the levels of asparagine aminotransferase(AST),alanine aminotransferase(ALT)and glutamyltransferase(GGT)levels were detected by colorimetry,the levels of total bilirubin(TBIL)and direct bilirubin(DBIL)were detected by automatic biochemical analyzer,Pearson was used to analyze the correlation between levels of serum LECT2 and the level of AST,GGT,ALT,DBIL and TBIL.Results The levels of serum LECT2,AST,ALT,DBIL,TBIL and GGT in the advanced stage patients were higher than those in the remission stage patients and the control group(all P<0.05),while there was no significant difference in the above indexes between remission group and control group(all P>0.05).The levels of serum LECT2,AST,ALT,GGT,DBIL and TBIL in the uncured group were higher than those in improved group and control group(all P<0.05),while there was no significant difference in the above indexes between improved group and control group(P>0.05).Pearson correlation analysis showed that serum level of LECT2 was positively correlated with levels of serum AST,GGT,ALT,DBIL and TBIL in patients with autoimmune liver disease(r=0.360,0.491,0.431,0.316,0.452,all P<0.05).Conclusion LECT2 is highly expressed in serum of patients with autoimmune liver disease,and it is positively correlated with the levels of serum AST,GGT,ALT,DBIL and TBIL.The level of serum LECT2 may be used as an index to evaluate the severity of the disease.

关 键 词：自身免疫性肝病 白细胞衍生趋化因子2 临床意义 肝功能 

分 类 号：R575[医药卫生—消化系统]