抗转录中介因子1γ抗体IgG阳性的无肌病性皮肌炎合并卵巢癌2例及文献复习  

Two cases of amyopathic dermatomyositis concurrent with ovarian cancer with IgG-positive anti-TIF1γantibodies

作　　者：曹妍[1] 常红芹[1] 郭盛华[1] 梁宁[1] CAO Yan;CHANG Hong-qin;GUO Sheng-hua;LIANG Ning(Department of Dermatology,the Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University,Changzhou 213000,China)

机构地区：[1]南京医科大学附属常州市第二人民医院皮肤科,江苏常州213000

出　　处：《临床皮肤科杂志》2021年第10期604-608,共5页Journal of Clinical Dermatology

摘　　要：目的:探讨无肌病性皮肌炎合并卵巢癌的临床特点、诊断和预后。方法:回顾性分析2例抗转录中介因子(TIF)1γ抗体IgG阳性的无肌病性皮肌炎合并卵巢癌患者的临床资料,并进行文献复习。结果:2例患者年龄均>40岁,皮损以曝光部位为主,实验室检查提示血清肌酸激酶(CK)正常、乳酸脱氢酶(LDH)升高,血清肿瘤指标CA125明显升高,肌炎特异性抗体TIF1γ抗体IgG阳性,且患者在卵巢癌手术治疗后1个月皮损均得到明显缓解。结论:无肌病性皮肌炎与卵巢癌的发生和发展呈正相关,治疗以手术治疗或联合化疗为主。>40岁的无肌病性皮肌炎女性患者应筛查血清肿瘤指标、TIF1γ抗体、盆腔超声及增强CT等,以警惕卵巢癌的发生。Objective:To investigate the clinical features,diagnosis and prognosis of amyopathic dermatomyositis concurrent with ovarian cancer.Methods:The clinical data of two cases of amyopathic dermatomyositis concurrent with ovarian cancer with IgG-positive anti-TIF1γantibodies were retrospectively analyzed.Results:Both patients were older than 40 years old,and the rashes were mainly in photoexposed areas.The laboratory examination showed that the CK was normal,LDH was elevated,serum tumor index CA125 was significantly increased,and anti-TIF1γantibody was positive for IgG.The rashes were significantly relieved in one month after the excision of ovarian cancer.Conclusion:Amyopathic dermatomyositis is positively correlated with the occurrence and development of ovarian cancer.The treatment is mainly based on surgery or its combination with chemotherapy.Female patients with amyopathic dermatomyositis over 40 years old should be screened for serum tumor markers,anti-TIF1γantibodies,pelvic ultrasound and enhanced CT,etc.,to predict the occurrence of ovarian cancer.

关 键 词：皮肌炎 无肌病性 卵巢癌 文献复习 

分 类 号：R739.5[医药卫生—肿瘤]