直肠癌根治术后复发时间影响因素分析  

Analysis of recurrence factors for rectal cancer after radical operation

作　　者：曹思齐 庄小云 林艺丹 黄凯利 陈水宝 戴雅兰 戴永美[2,3] CAO Siqi;ZHUANG Xiaoyun;LIN Yidan;HUANG Kaili;CHEN Shuibao;DAI Yalan;DAI Yongmei(Fujian Medical University,Fuzhou 350108,China;Provincial Clinical Medical College,Fujian Medical University,Fuzhou 350004,China;Department of Oncology,Fujian Provincial Hospital,Fuzhou 350004,China)

机构地区：[1]福建医科大学,福建福州350108 [2]福建医科大学省立临床医学院,福建福州350004 [3]福建省立医院肿瘤内科,福建福州350004

出　　处：《肿瘤基础与临床》2021年第5期382-385,共4页journal of basic and clinical oncology

基　　金：福建省自然科学基金资助项目(2017J01245)。

摘　　要：目的探讨直肠癌患者根治术后复发时间与相关临床病理因素的关系。方法回顾性分析福建省立医院2012年11月至2017月10月收治的16例直肠癌术后复发患者的临床病理资料,应用Kaplan-Meier单因素回归分析和多因素Cox回归分析进行术后复发影响因素分析。结果单因素分析显示,年龄、术前排便习惯是否改变、治疗前肿瘤分化程度和术后K-ras基因状态与术后复发时间有关;多因素分析显示,性别和家族肠病史与术后复发时间有关。结论术前排便习惯是否改变、性别和家族肠病史是直肠癌术后复发时间相关的影响因素,加强早期诊断和科学、规范的治疗有望改善直肠癌预后。Objective To investigate the correlation between clinical factors and recurrence time in the patients with rectal cancer after radical resection of rectal carcinoma,and to explore the ways to improve the efficacies.Methods A total of 16 postoperative cases of rectal cancer from January 2012 to October 2017 were recruited.And the relation ship between each clinicopathologic characteristic and local post-operative recurrence was retrospectively investigated.The clinicopathologic factors and follow-up data were analyzed by Kaplan-meier analysis and Cox regression which were used to establish univariate and multivariate regression models.Results Univariatcan analysis showed that changes in age,preoperative bowel habits,preoperative tumor differentiation and postoperative K-ras gene status were associated with time to postoperative recurrence.And further multivariate analysis showed that gender and family history were associated with time to postoperative recurrence.Conclusion Changes in preoperative bowel habits,gender and family history of bowel disease were correlated to recurrence time in patients with postoperative colorectal cancer.It is possible to improve the prognosis of rectum cancer by making an early diagnosis and offering a scientific standard therapy.

关 键 词：直肠癌 根治性手术 复发时间 危险因素 

分 类 号：R735.37[医药卫生—肿瘤]