妊娠晚期孕妇高危型HPV感染及危险因素分析  

Analysis of high-risk papilloma virus infection situation and related risk factors of pregnant women during the third trimester of pregnancy

作　　者：蔡春苗 符爱贞 翁叶蕊 CAI Chunmiao;FU Aizhen;WENG Yerui(Haikou Maternal and Child Health Care Hospital, Hainan Province, 570203)

机构地区：[1]海南省海口市妇幼保健院,570203

出　　处：《中国计划生育学杂志》2021年第9期1804-1807,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠晚期孕妇高危型人乳头瘤病毒(HPV)感染情况并分析危险因素。方法:2017年1月—2020年12月在本院产科门诊进行HPV筛查及HPV分型检测的妊娠晚期孕妇4600例,通过调查问卷、临床资料分析等方式进行流行病学调查,分析相关危险因素。结果:发放调查问卷4600例,收回有效问卷4469例,有效率为97.2%。4469例中434例感染高危型HPV(9.7%)。感染率较高的高危型HPV亚型为HPV16(1.4%)、HPV52(1.2%),感染单一型为61.8%,双重型为23.7%,多重型为14.5%。单因素分析显示,孕妇年龄、孕次、首次妊娠年龄、孕期性行为、性伴侣、爱人婚外关系、宫颈炎、阴道分泌物异常是妊娠晚期孕妇高危型HPV感染风险(P<0.05),孕妇年龄、产次、吸烟史、饮酒史、尿路感染等因素无差异(P>0.05)。logistic逐步回归分析显示,孕期性行为、性伴侣、爱人婚外关系、宫颈炎是妊娠晚期孕妇感染高危型HPV的独立危险因素(P<0.05)。结论:本次调查高危型HPV感染优势亚型为HPV16和HPV52。可针对本地区感染高危型HPV危险因素加强孕妇的宣传干预。Objective:To explore the situation of high-risk human papilloma virus(HPV)infection and the related risk factors of pregnant women during the third trimester of pregnancy in Haikou area,and to analyze the related risk factors of the high-risk HPV infection.Methods:A total of 4600 pregnant women during the third trimester of pregnancy who underwent HPV screening and HPV typing test were selected in this study from January 2017 to December 2020.The epidemiological investigation of high-risk HPV infection of the pregnant women during the third trimester of pregnancy was conducted by questionnaire and clinical data analysis,and the related risk factors were analyzed.Results:Among the 4600 women who received the questionnaire,4469 women had returned the valid questionnaires with the rate of returned successful of 97.2%.In 4469 cases,there were 434 cases with high-risk HPV infection with the infection rate of 9.71%.The highest infection rates of high-risk HPV subtypes were HPV16 and HPV52,which’s infection rates were 1.4%and 1.2%,respectively.Univariate analysis showed that age,pregnancy number,age of the first pregnancy,sexual behavior during pregnancy,sexual partner,extramarital sexual partner of husband,sexual partner,cervicitis,abnormal vaginal secretion of the pregnant women were the risk of high-risk HPV infection of the pregnant women during the third trimester of pregnancy(P<0.05),while delivery number,smoking history,drinking history,urinary tract infection and other factors were not the factors of high-risk HPV infection(P>0.05).The results of logistic stepwise regression analysis model showed that sexual behaviour during pregnancy,sexual partners,extramarital sexual partner of husband,and cervicitis were the independent risk factors of high-risk HPV infection(P<0.05).Conclusion:The prevalent dominant subtypes of high-risk HPV infection among pregnant women during the third trimester of pregnancy in Haikou area are HPV16 and HPV52.The publicity and intervention for the pregnant women can be strengthened acc

关 键 词：妊娠晚期孕妇 高危型人乳头瘤病毒 感染率 危险因素 

分 类 号：R73[医药卫生—肿瘤]