垂体后叶素联合腹腔镜切除术治疗良性子宫肌瘤疗效及安全性  

Clinical efficacy and safety of pituitrin combined with laparoscopic myomectomy for treating patients with benign hysteromyoma

作　　者：宋玮[1] 刘华[1] SONG Wei;LIU Hua(Ruijin Hospital Affiliated to School of Medicine of Shanghai Jiao Tong University,Shanghai, 20025)

机构地区：[1]上海交通大学医学院附属瑞金医院,200025

出　　处：《中国计划生育学杂志》2021年第9期1854-1857,共4页Chinese Journal of Family Planning

摘　　要：目的:分析垂体后叶素联合腹腔镜术治疗良性子宫肌瘤的临床疗效及安全性。方法:选取2018年3月—2020年3月在本院行腹腔镜子宫肌瘤切除术的良性子宫肌瘤患者332例,随机数字表法分为后叶素组182例和缩宫素组150例。两组均行腹腔镜子宫肌瘤挖除术,后叶素组术中一次性宫体注射垂体后叶素12U,缩宫素组术中注射缩宫素20U,比较两组手术疗效及安全性。结果:后叶素组与缩宫素组手术时间(88.0±24.2min比111.5±28.9min)、术中出血量(57.8±20.8 ml比197.3±31.0 ml)、住院时间(4.9±1.1d比8.8±1.4d)均减少(P<0.05),术后排气时间无差异(P>0.05)。两组患者用药后收缩压(SBP)、舒张压(DBP)、心率(HR)均发生波动(P<0.05),且用药后5min时后叶素组SBP高于缩宫素组,DBP及HR低于缩宫素组(P<0.05),其余时刻两组无差异(P>0.05)。后叶素组术后感染发生率(2.8%)低于缩宫素组(8.0%)(P<0.05),两组术后血肿、发热、延迟愈合、低血压并发症无差异(P>0.05)。结论:垂体后叶素与缩宫素分别辅助腹腔镜子宫肌瘤切除术治疗良性子宫肌瘤均有确切疗效,但应用垂体后叶素在减少出血、缩短手术时间、降低术后感染方面更具优势。Objective:To analyze the clinical efficacy and safety of pituitrin combined with laparoscopic myomectomy for treating patients with benign hysteromyoma.Methods:A total of 332 patients with benign hysteromyoma who underwent laparoscopic myomectomy were selected and were randomly divided into study group and control group by random number table method from March 2018 to March 2020.182patients in the study group were given one-time uterus injection of pituitrin 12U during operation,and 150 patients in the control group were given one-time uterus injection of oxytocin 20U during operation.The efficacy and safety of the patients were compared between the two groups.Results:The operating time(88.0±24.2 min),the intraoperative blood loss(57.8±20.8 ml),and the hospital stay time(4.9±1.1d)of the patients in the study group were all significant shorter than those(111.5±28.9min,197.3±31.0ml,and 8.8±1.4d)of the patients in the control group(P<0.05),but the postoperative exhaust time of the patients had no significant different between the two groups(P>0.05).The values of systolic blood pressure(SBP),diastolic blood pressure(DBP),and heart rate(HR)of the patients in the two groups had been volatility significantly after medicine used(P<0.05).5 min after medicine used,the SBP value of the patients in the study group was significant higher than that of the patients in the control group,but the values of DBP and HR of the patients in the study group were significant lower than those of the patients in the control group(P<0.05),and the values of SBP,DBP,and HR of the patients at rest time had no significant different between the two groups(P>0.05).The incidence of postoperative infection(2.8%)of the patients in the study group was significant lower than that(8.0%)of the patients in the control group(P<0.05),but the rates of postoperative hematoma,fever,delayed healing,and other complications,such as low blood pressure of the patients had no significant different between the two groups(P>0.05).Conclusion:Pituitrin or oxytoci

关 键 词：良性子宫肌瘤 腹腔镜 子宫肌瘤切除术 垂体后叶素 缩宫素 临床疗效 安全性 

分 类 号：R73[医药卫生—肿瘤]