MMR蛋白表达与不同子宫内膜病变类型的相关性  

The relationship between the mismatch repair protein expression level of patients and their different types of endometrial lesions

作　　者：刘晓娟[1] 马会[1] 马丽莎 李坤[1] LIU Xiaojuan;MA Hui;MA Lisha;LI Kun(The First Affiliated Hospital of North University, Zhangjiakou, Hebei Province,075000;Zhangjiakou Infectious Disease Hospital)

机构地区：[1]河北北方学院附属第一医院,张家口075000 [2]河北省张家口市传染病医院

出　　处：《中国计划生育学杂志》2021年第9期1947-1950,共4页Chinese Journal of Family Planning

基　　金：河北省卫生健康委科研基金项目(20211493)。

摘　　要：目的:探究子宫内膜病变与错配修复基因(MMR)表达相关性。方法:回顾性收集2017年1月—2019年12月于本院治疗的子宫内膜病变患者180例,包括子宫内膜息肉、子宫内膜不典型增生、子宫内膜癌各60例。收集组织样本进行MMR蛋白检测,分析子宫内膜病变及子宫内膜癌MMR蛋白表达与临床病理指标差异性。结果:3组患者中,子宫内膜癌患者年龄、功能丧失的dMMR发生率(33.3%),MLH1(23.3%)、PMS2(23.3%)表达缺失比例,均高于子宫内膜不典型增生和子宫内膜息肉患者(P<0.05)。子宫内膜癌dMMR发生与肌层浸润增加有关(P<0.05)。结论:MMR蛋白可能参与了子宫内膜病变的发生发展。Objective:To investigate the relationship between the mismatch repair(MMR)gene expression level of patients and their endometrial lesions.Methods:180 patients with endometrial lesions from January 2017 to December 2019 were collected retrospectively,which included 60 patients with endometrial polyp in group A,60 patients with endometrial atypical hyperplasia in group B,and 60 patients with endometrial cancer in group C.Tissue samples of the patients in the three groups were collected for detecting MMR protein expression level.The expression level of MMR protein in endometrial lesions tissues and the difference of the MMR protein expression and clinicopathological indexes in endometrial cancer tissue of the patients were analyzed.Among the three groups,the age and the incidence of deficiency of MMR(33.3%)of the patients in group C were the highest.The incidence of deficiency of MLH1(23.3%)and the level of PMS2(23.3%)of the patients in group C were also the highest,and which were significant higher than those of the patients in group A and B(P<0.05).The incidence of deficiency of MMR in endometrial cancer tissue was associated with the increased muscular invasion of cancer(P<0.05).Conclusion:MMR protein plays an important role in the occurrence and development of endometrial lesions.

关 键 词：子宫内膜病变 错配修复蛋白 免疫组织化学 病理特征关系 

分 类 号：R737.33[医药卫生—肿瘤]