高危型HPV感染不孕患者免疫功能状态及辅助生殖临床结局  

The immune function status and clinical outcomes of infertile patients with high-risk human papilloma virus infection after assisted reproductive technology

作　　者：张烨琳 沈醒杭[1] 姚冬莉[1] ZHANG Yelin;SHEN Xinghang;YAO Dongli(Hangzhou Hospital of Traditional Chinese Medicine, Zhejiang Province, 310007)

机构地区：[1]浙江省杭州市中医院,310007

出　　处：《中国计划生育学杂志》2021年第9期1979-1982,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨高危型人乳头瘤病毒(HPV)感染的不孕患者免疫功能状态,分析采用辅助生殖技术(ART)临床结局。方法:选择2017年1月—2019年12月在本院诊治的高危型HPV感染不孕患者97例为感染组,其中合并解脲脲原体(UU)感染33例,单一感染64例,高危型为HPV1639例、HPV1831例,其他27例。HPV感染阴性不孕患者97例为对照组。比较各组T淋巴细胞亚群,以及与高危型HPV不孕患者ART妊娠结局关系。结果:感染组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、自然杀伤细胞(NK)低于对照组,而CD8^(+)高于对照组(P<0.05);不同高危型HPV感染患者CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、NK均无差异(P>0.05),单一高危型HPV感染患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK均高于合并UU感染者,而CD8^(+)低于合并UU感染者(P<0.05)。高危型HPV感染不孕患者妊娠成功38例(39.2%),妊娠成功者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK高于妊娠失败者,而CD8^(+)低于妊娠失败者(P<0.05)。结论:高危型HPV感染不孕患者存在免疫功能紊乱,且合并UU感染的患者免疫功能紊乱状况更差,ART妊娠失败与免疫功能紊乱有关。Objective:To investigate the immune function status of infertile patients with high-risk human papilloma virus(HPV)infection,and to analyze the clinical outcomes of these patients after assisted reproductive technology(ART).Methods:97 infertility patients with high-risk HPV infection were selected in research group from January 2017 to December 2019,which included 33 cases with ureaplasma urealyticum(UU)infection,64 cases with single HPV subtype infection,39 cases with HPV16 subtype infection,31 cases with HPV18 subtype infection,and 27 cases with other HPV subtype infection.97 infertility patients without HPV infection were selected in control group.The T lymphocyte subsets status of the patients was compared between the two groups.The relationship between the T lymphocyte subsets status of the infertility patients with high-risk HPV infection and their pregnancy outcomes after ART was analyzed.Results:The values of CD3^(+),CD4^(+),CD4^(+)/CD8^(+),and natural killer cells(NK)of the patients in the research group were significant lower than those of the patients in the control group(P<0.05),but the CD8^(+) value of the patients in the research group was significant higher(P<0.05).There were no statistically significant different in the values of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and NK among the patients with different high-risk HPV subtypes infection(P>0.05).The values of CD3^(+),CD4^(+),CD4^(+)/CD8^(+),and NK of the patients with single high-risk HPV infection were significant higher than those of the patients with high-risk HPV and UU infection(P<0.05),but the value of CD8^(+) of the patients with single high-risk HPV infection was significant lower(P<0.05).38(39.2%)infertility patients with high-risk HPV infection had successful pregnancy.The values of CD3^(+),CD4^(+),CD4^(+)/CD8^(+) and NK of the patients with successful pregnancy were significant higher than those of the patients with pregnancy failure(P<0.05),but the CD8^(+) value of the patients with successful pregnancy was significant lower(P<0.05

关 键 词：不孕 高危型人乳头瘤病毒 T淋巴细胞亚群 自然杀伤细胞 辅助生殖技术 妊娠结局 

分 类 号：R737.33[医药卫生—肿瘤] R711.6[医药卫生—临床医学]