HB-EGF在宫颈鳞状上皮内病变及宫颈癌中的表达情况  

Expression and significance of HB-EGF in cervical squamous intraepithelial lesions and cervical cancer

作　　者：赵志敏[1] 孔继光 林晓凤[2] 林少香 ZHAO Zhimin;KONG Jiguang;LIN Xiaofeng;LIN Shaoxiang(Department of Clinical Laboratory;Department of Pathology,Maternal and Child Health Hospital of Longgang District,Shenzhen,Guangdong 518000,China)

机构地区：[1]广东省深圳市龙岗区妇幼保健院检验科,广东深圳518000 [2]广东省深圳市龙岗区妇幼保健院病理科,广东深圳518000

出　　处：《检验医学与临床》2021年第21期3090-3092,共3页Laboratory Medicine and Clinic

基　　金：广东省深圳市龙岗区科技创新局医疗卫生科技计划项目(LGKCYLWS2018000167)。

摘　　要：目的探讨肝素结合表皮生长因子(HB-EGF)在宫颈低级别鳞状上皮内病变(LSIL)、高级别鳞状上皮内病变(HSIL)及宫颈癌组织中的表达情况。方法选取2018年7月至2020年6月该院病理科保存的组织标本为研究对象,包括宫颈癌组织标本83例,HSIL组织标本239例,LSIL组织标本245例,宫颈炎组织标本150例。采用免疫组织化学法检测HB-EGF在上述4种组织中的表达情况,并对比其表达差异。结果HB-EGF在宫颈炎组织的上皮基底层及部分间质细胞中少量表达,而在LSIL、HSIL及宫颈癌组织的上皮及间质细胞中表达明显增加。HB-EGF在宫颈炎、LSIL、HSIL及宫颈癌组织中的表达阳性率分别为8.0%、43.7%、100.0%、100.0%。结论HB-EGF在HSIL及宫颈癌组织中高表达,有望成为HSIL及宫颈癌诊断及治疗的新标志物或靶点。Objective To investigate the expression of heparin-binding epidermal growth factor(HB-EGF)in cervical low-grade squamous intraepithelial lesion(LSIL),high-grade squamous intraepithelial lesion(HSIL)and cervical cancer tissues.Methods Tissue specimens preserved in the department of pathology of the hospital from July 2018 to June 2020 were selected as the research objects,including 83 cervical cancer tissue specimens,239 HSIL tissue specimens,245 LSIL tissue specimens,and 150 cervicitis tissue specimens.The immunohistochemical method was used to detect the expression of HB-EGF in the above four tissues and compare their expression differences.Results HB-EGF was expressed in the epithelial basal layer of cervicitis tissues and a small amount of mesenchymal cells,while the expression of LSIL,HSIL and the epithelial and mesenchymal cells of cervical cancer tissues increased significantly.The positive rates of HB-EGF expression in cervicitis,LSIL,HSIL and cervical cancer tissues were 8.0%,43.7%,100.0%,and 100.0%,respectively.Conclusion HB-EGF is highly expressed in HSIL and cervical cancer tissues,and it is expected to become a new marker or target for the diagnosis and treatment of HSIL and cervical cancer.

关 键 词：肝素结合表皮生长因子 宫颈癌 宫颈鳞状上皮内病变 肿瘤标志物 

分 类 号：R737.33[医药卫生—肿瘤]