内镜下射频消融术治疗功能性烧心患者的临床疗效研究  

Study on the clinical efficacy of endoscopic radiofrequency ablation in the treatment of patients with functional heartburn

作　　者：龚燕 陈镇 GONG Yan;CHEN Zhen(Department of Gastroenterology,Santai County People′s Hospital,Mianyang,Sichuan 621100,China;Department of Gastroenterology,Xi′an Honghui Hospital,Xi′an,Shaanxi 710068,China)

机构地区：[1]四川省绵阳市三台县人民医院消化内科,四川绵阳621100 [2]陕西省西安市红会医院消化内科,陕西西安710068

出　　处：《检验医学与临床》2021年第21期3160-3163,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨内镜下射频消融术治疗功能性烧心(FH)患者的临床疗效。方法回顾性分析2017-2019年三台县人民医院收治的41例FH患者相关临床资料,其中采用莫沙比利联合奥美拉唑治疗的为对照组(n=20),采用内镜下射频消融术联合莫沙比利、奥美拉唑治疗的为观察组(n=21),所有患者均出院后随访12个月。比较两组患者烧心、胸痛症状评分,高分辨率食管测压结果,24 h食管阻抗-pH监测结果。结果治疗后随访12个月,观察组患者烧心、胸痛症状评分低于对照组,差异有统计学意义(P<0.05);观察组患者远端收缩积分、食管下括约肌静息压高于对照组,而收缩前沿速度、食团内部压力低于对照组,差异均有统计学意义(P<0.05);观察组患者总反流次数、酸反流次数、弱酸反流次数、非酸反流次数均低于对照组,差异均有统计学意义(P<0.05);观察组患者出现1例消化道少量出血。结论针对FH患者,内镜下射频消融术可改善食管下括约肌的松弛,降低反流频次,改善患者临床症状。Objective To investigate the clinical efficacy of endoscopic radiofrequency ablation in the treatment of patients with functional heartburn(FH).Methods A retrospective analysis of the relevant clinical data of 41 FH patients admitted to the Santai County People′s Hospital from 2017 to 2019.Among them,the control group(n=20)treated with mosapride combined with omeprazole was treated with endoscopic radiofrequency.The observation group(n=21)was treated with endoscopic radiofrequency ablation combined with mosapride and omeprazole.All patients were followed up for 12 months after discharge.The scores of heartburn and chest pain symptoms,the results of high-resolution esophageal pressure measurement,and the results of 24 h esophageal impedance-pH monitoring were compared between the two groups.Results Followed up for 12 months after treatment,the heartburn and chest pain symptom scores of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The scores of distal contraction and resting pressure of the lower esophageal sphincter in the observation group were higher than those in the control group,while the frontal contraction speed and internal pressure of the esophagus were lower than those in the control group,the differences were statistically significant(P<0.05).The total number of reflux times,acid reflux times,weak acid reflux times,and non-acid reflux times in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).One case of gastrointestinal bleeding occurred in the observation group.Conclusion For FH patients,endoscopic radiofrequency ablation can reduce the frequency of reflux by improving the relaxation of the lower esophageal sphincter and improve the clinical symptoms of the patients.

关 键 词：内镜下射频消融术 功能性烧心 临床疗效 反流 

分 类 号：R571[医药卫生—消化系统]