c-Myc regulates neural stem cell quiescence and activation by coordinating the cell cycle and mitochondrial remodeling  

作　　者：Chunhui Cai Xinyu Hu Peibin Dai Tianran Zhang Mei Jiang Liefu Wang Wanhao Hua Yantao Fan Xin-Xin Han Zhengliang Gao 

机构地区：[1]Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),Tongji University School of Medicine,Shanghai,China [2]Institute of Geriatrics(Shanghai University),Affiliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong),School of Medicine,Shanghai University,Nantong,China [3]Shanghai Engineering Research Center of Organ Repair,School of Medicine,Shanghai University,Shanghai,China [4]Xinyang Vocational and Technical College,Xinyang,Henan,China [5]Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases,Shanghai Stomatological Hospital,Fudan University,Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第9期2628-2630,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by funds from the National Key R&D Program of China(2019YFA0110300,2017YFA0104100);Shanghai Easter Scholar(8101219003)to Z.L.G.;the National Natural Science Foundation of China(31600819 to C.H.C.,81773302 to Y.T.F.,31571058 and 32070862 to Z.L.G.,31701282 to M.J.,and 81901031 to X.X.H.);Shanghai Municipal Planning Commission of science and Research Fund(20174Y0216)to C.C.H.;the Natural Science Foundation of Shanghai(19ZR1445400)to X.X.H.

摘　　要：Dear Editor,In the adult brain,the transition from neural stem cell(NSC)quiescence to activation is a focal regulatory point for neural regeneration and dysregulations in the transition lead to brain disorders.1,2 During this transition,both cell cycle states and metabolism including mitochondria undergo extensive reprogramming.A deep understanding of such comprehensive changes is a prerequisite for a holistic picture of physiology and may aid disease combats.

关 键 词：metabolism neural ACTIVATION 

分 类 号：R74[医药卫生—神经病学与精神病学]