Liquid-liquid phase separation in human health and diseases  

作　　者：Bin Wang Lei Zhang Tong Dai Ziran Qin Huasong Lu Long Zhang Fangfang Zhou 

机构地区：[1]Department of Orthopaedic Surgery,The Third Affiliated Hospital of Wenzhou Medical University,Rui’an,People’s Republic of China [2]MOE Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,Hangzhou,People's Republic of China [3]lnstitutes of Biology and Medical Science,Soochow University,Suzhou,People's Republic of China

出　　处：《Signal Transduction and Targeted Therapy》2021年第9期2634-2649,共16页信号转导与靶向治疗（英文）

基　　金：This work was supported by a special program from the Ministry of Science and Technology of China(2016YFA0502500 to L.Z.);the Chinese National Natural Science Funds(31925013,31671457,and 91753139 to L.Z.;31871405 and 31571460 to FZ.;92053114,32070632 to H.L.);Zhejiang Provincial Natural Science Foundation of China under Grant(LBY21H060001 to L.Z.);the Medical and the Medical and Health Research Project of Zhejiang Province(2020RC115 to L.Z.);Jiangsu National Science Foundation(BK20180043 and 19KJA550003 to F.Z.);the Zhejiang Natural Science Fund(LD19C070001to L.Z.);the China National Postdoctoral Program for Innovative Talents(BX2021208 to T.D.);the China Postdoctoral Science Foundation(2021M692350 to T.D.);the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003);A project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

摘　　要：Emerging evidence suggests that liquid-liquid phase separation(LLPS)represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells(also known as biomolecular condensates or droplets).Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases.In this review,we describe our current understanding of LLPS and summarize its physiological functions.We further describe the role of LLPS in the development of human diseases.Additionally,we review the recently developed methods for studying LLPS.Although LLPS research is in its infancy-but is fast-growing-it is clear that LLPS plays an essential role in the development of pathophysiological conditions.This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries.

关 键 词：SEPARATION DISEASES LIQUID 

分 类 号：R318[医药卫生—生物医学工程]