土贝母苷甲抗肿瘤作用机制研究进展  

Research progress on the Anti-solid tumor mechanism of TBMSⅠ

作　　者：王中会 晁旭[1,2] 吕天依 胡锦丹 闫平慧[1] WANG Zhonghui;CHAO Xu;LYU Tianyi;HU Jindan;YAN Pinghui(Shaanxi University of Chinese Medicine,Xi’an 712046,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学第二附属医院,陕西咸阳712046

出　　处：《陕西中医》2021年第11期1652-1656,F0003,共6页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81774132);陕西省科技计划项目(2020SF-324);陕西中医药大学消化病肿瘤分子机制及中西医结合防治基础研究创新团队课题(2019-YS05)。

摘　　要：天然化合物是抗癌药物的重要来源。土贝母苷甲(TBMSⅠ)是土贝母的主要药理活性成分,大量实验研究证实TBMSⅠ在体内外不同的致癌阶段都具有抗癌活性。TBMSⅠ通过多种信号通路抑制癌细胞的生长和增殖,诱导细胞周期阻滞、凋亡、分化、自噬,抑制血管生成、侵袭和转移。TBMSⅠ联合化疗药治疗还可增强耐药癌细胞的敏感性。现就TBMSⅠ在各肿瘤系统中的抗肿瘤作用的临床前研究及其分子机制进行综述和分析,并对其在肿瘤防治中的应用前景进行展望。TBMSⅠ作为相关候选药物的潜力可以被适当地开发和设计成一种有效的抗癌药物。Natural compounds are important sources of anticancer drugs.TubeimosideⅠ(TBMSⅠ)is the main pharmacologically active component of rhizoma bolbostemmatis.Extensive researches have provided evidences of the anticancer activities of TBMSⅠin different stages of carcinogenesis both in vitro and in vivo model.TBMSⅠcould inhibit cell growth and proliferation,induce cell differentiation,apoptosis,autophagy and,suppress angiogenesis,invasion and metastasis via various signaling pathways.Combination of TBMSⅠwith chemotherapeutic agents also enhanced the sensitivity of drug-resistant cancer cells.This mini-review aims to summarize and analyze the current knowledge on the pre-clinical studies of anti-tumor effects,the underlying molecular mechanisms in various tumor systems and discuss the prospects of the application of TBMSⅠin cancer prevention and treatment.The potential of TBMSⅠas pertinent candidates could be appropriately developed and designed into an efficacious anticancer drug.

关 键 词：肿瘤 土贝母苷甲 抗癌特性 分子机制 肿瘤系统 

分 类 号：R73[医药卫生—肿瘤]