白金丸加味治疗非酒精性脂肪肝45例临床观察  

Clinical Observation on 45 Cases of Nonalcoholic Fatty Liver Treated with Modified Baijin Pill(白金丸)

作　　者：孙建强 顾佳琳 夏正 沈铭轩 SUN Jianqiang;GU Jialin;XIA Zheng;SHEN Mingxuan(Jiangsu Shengze Hospital Affiliated to Nanjing Medical University,Suzhou 215228,Jiangsu,China)

机构地区：[1]南京医科大学附属江苏盛泽医院,江苏苏州215228

出　　处：《实用中医内科杂志》2021年第9期107-110,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：江苏省中医药局科技项目(YB2015132)。

摘　　要：目的观察白金丸加味治疗非酒精性脂肪肝的临床疗效。方法将90例患者随机分为2组,治疗组45例予白金丸加味汤药(白矾10 g,郁金20 g,炒白术15 g,云茯苓15 g,猪苓15 g,泽泻15 g,春柴胡10 g,酒黄芩10 g,姜半夏10 g,浙贝母10 g,紫丹参15 g,生山楂15 g生葛根10 g,怀牛膝10 g)口服,1剂/d,水煎至300 mL,分早晚2次温服,对照组45例予复方益肝灵片口服,3次/d, 4片/次,两组疗程均为12周。观察临床症状,如胁肋胀痛、纳差、乏力等改善情况,B超声像改善情况,实验室检查指标,如丙氨酸氨基转移酶、天门冬氨基转移酶、谷氨酰转肽酶。结果两组患者经治疗后,胁肋胀痛、纳差、乏力等症状以及丙氨酸氨基转移酶、天门冬氨基转移酶、谷氨酰转肽酶等肝功能指标均有明显改善(P<0.05),但组间比较无显著差异(P>0.05)。两组患者治疗后B超声像均有所改善,改善情况的总有效率分别为:治疗组为91.11%(41/45),对照组为66.67%(30/45)。治疗组优于对照组,差异具有统计学意义(P<0.05)。临床总疗效方面,两组均有一定的临床效果,治疗组痊愈率为31.11%(14/45)、总有效率为88.89%(40/45);对照组痊愈率为15.56%(7/45)、总有效率为64.44%(29/45),治疗组临床总疗效明显优于对照组(P<0.05)。结论白金丸加味可以有效治疗非酒精性脂肪肝。这可能与非酒精性脂肪肝痰瘀互结这一病机特点有关。Objective To observe the clinical curative effect of Baijin Pill(白金丸) on nonalcoholic fatty liver disease.Methods Ninety patients were randomly divided into two groups. The treatment group(45 cases) were given Modified Baijin Pill which was decocted to 300 mL,one dose a day, 2 times/d, while the control group(45 cases) were given Compound Yiganling, 3 times/d, 4 tablets per time. The course of treatment was 12 weeks in both groups. The clinical symptoms, such as the symptoms of distending pain in hypochondrium, anorexia, fatigue, liver function indexes such as ALT,AST, GGT and the B-ultrasound imageswere observed.Results After treatment, the symptoms of distending pain in hypochondrium, anorexia, fatigue and liver function indexes such as alanine aminotransferase, asparagus aminotransferase and glutamyltranspeptidase were significantly improved(P<0.05), but there was no significant difference between the two groups(P>0.05).The B-ultrasound images of the two groups were improved after treatment, and the total effective rate of improvement was 91.11%(41/45) in the treatment group and 66.67%(30/45) in the control group. The treatment group was better than the control group, and the difference was statistically significant(P<0.05).In terms of clinical total efficacy, the cure rate of the treatment group was 31.11%(29/45), and the total effective rate was 88.89%(40/45). The cure rate of the control group was 15.56%(7/45), and the total effective rate was 64.4%. The total clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).Conclusion Baijin Pill can effectively treat non-alcoholic fatty liver. This may be related to that the pathogenesis of non-alcoholic fatty liver is phlegm and blood stasis.

关 键 词：白金丸 非酒精性脂肪肝 痰瘀互结 复方益肝灵片 丙氨酸氨基转移酶 天门冬氨基转移酶 谷氨酰转肽酶 

分 类 号：R575.5[医药卫生—消化系统]