叶酸及其代谢酶基因与宫颈癌相关性的研究综述  

A review of the relationship between folic acid and its metabolizing enzyme gene and cervical cancer

作　　者：蒋瑜羽 王东红 JIANG Yuyu;WANG Donghong(Department of Gynecology,the Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou,563003,China)

机构地区：[1]遵义医科大学附属医院妇科,贵州遵义563003

出　　处：《肿瘤药学》2021年第5期535-538,共4页Anti-Tumor Pharmacy

摘　　要：宫颈癌是常见的妇科恶性肿瘤之一,其发生发展是多因素共同作用的复杂过程。有研究显示,缺乏叶酸可能导致宫颈癌。MTHFR基因及MTRR基因是影响叶酸水平的重要因素,其编码的蛋白是叶酸代谢通路的关键酶。MTHFR是一种能将5,10-亚甲基四氢叶酸还原为5-甲基四氢叶酸的关键酶,维持着DNA的正常甲基化反应,这是叶酸代谢循环的主要形式。MTRR是一种辅助酶,有研究报道其基因多态性与癌症的发生具有相关性。但叶酸缺乏是否系宫颈鳞癌的致病因素或增加其易感性,现有的研究仍存在争议且尚无定论。因此,本文旨在对叶酸水平及参与其代谢的关键酶基因多态性与宫颈癌相关性的研究进展进行综述。Cervical cancer is one of the common gynecological malignant tumors.The occurrence and development of cervical cancer is a complex process in which multiple factors work together.A lack of folic acid has been linked to cervical cancer in some studies.MTHFR and MTRR genes are important factors in the expression level of folic acid.Both are key enzymes in folic acid metabolic pathways.MTHFR is a key enzyme that reduces 5,10-methylene tetrahydrofolate to 5-methyl-tetrahydrofolate,which provides the raw material for the methyl cycle and maintains the normal methylation of DNA.This is the main form of the folic acid cycle.MTRR is an auxiliary enzyme,and its gene polymorphism has been reported to be associated with the occurrence of cancer.However,whether folic acid deficiency is a risk factor or an increase in susceptibility to cervical carcinoma is controversial and inconclusive.Therefore,the purpose of this article is to review the progress of studies on the relationship between folic acid level and gene polymorphism of key enzymes involved in its metabolism and cervical carcinoma.

关 键 词：叶酸 MTHFR基因 MTRR基因 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]