根治性手术切除结直肠癌肺转移灶的临床疗效及预后效果分析  

Analysis of the Clinical Efficacy and Prognostic Effect of Radical Surgical Resection of Pulmonary Metastases from Colorectal Cancer

作　　者：杨常利 杨晓伟 张向东 Yang Changli;Yang Xiaowei;Zhang Xiangdong(Department of Anorectal Enterology,Dengfeng Hospital of Traditional Chinese Medicine,Dengfeng 452470)

机构地区：[1]河南省登封市中医院肛肠科,登封452470

出　　处：《数理医药学杂志》2021年第11期1614-1616,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨结直肠癌肺转移灶患者使用根治性手术切除治疗的价值及预后效果。方法:纳入2018年1月~2020年12月50例经影像学检查确诊为结直肠癌肺转移灶患者研究,按双盲法分为对照组(选用化疗)和观察组(选用根治性手术切除治疗)各25例,统计两组临床疗效、预后效果、血清肿瘤标志物水平。结果:观察组临床疗效(96.00%)高于对照组(68.00%),经检验P<0.05。观察组术后1年(80.00%)、2年(56.00%)生存率高于对照组,经检验P<0.05。治疗前两组血清肿瘤标志物水平CEA、CA19-9、CA242、CA724等对比无统计差异;治疗后1年观察组CEA、CA19-9、CA242、CA724低于对照组,经检验差异显著(t_(1)=22.081,P_(1)<0.001;t_(2)=23.769,P_(2)<0.001;t_(3)=34.238,P_(3)<0.001;t 4=8.413,P_(4)<0.001);治疗后2年观察组CEA、CA19-9、CA242、CA724低于对照组,经检验差异显著(t_(1)=30.239,P_(1)<0.001;t_(2)=33.416,P_(2)<0.001;t_(3)=23.569,P_(3)<0.001;t 4=12.203,P_(4)<0.001)。结论:根治性手术切除术在结直肠癌肺转移灶中应用中效果确切,既可提高其生存率,亦可降低血清肿瘤标志物水平,值得借鉴及参考。Objective:To investigate the value and prognostic effect of radical surgical resection in patients with pulmonary metastases from colorectal cancer.Methods:50 patients diagnosed with colorectal cancer lung metastases by imaging were included in the study(January 2018 to December 2020)and divided into control group(n=25,chemotherapy)and observation group(n=25,radical surgical resection)by the double-blind manner,and the clinical outcomes,prognostic effects,and serum tumor marker levels of the two groups were statistically analyzed.Results:The clinical efficacy was higher in the observation group(96.00%)than in the control group(68.00%)(P<0.05).Prognostic effect:The 1-yearand 2-year survival rates in the observation group(80.00%,56.00%)were higher than those in the control group(P<0.05).Serum levels of tumor markers:The CEA,CA19-9,CA242 and CA724 were not statistically different between the two groups before treatment.The CEA,CA19-9,CA242,CA724 were lower in the observation group than in the control group 1 year after treatment,with significant difference(t_(1)=22.081,P_(1)<0.001;t_(2)=23.769,P_(2)<0.001;t_(3)=34.238,P_(3)<0.001;t_(4)=8.413,P_(4)<0.001).The CEA,CA19-9,CA242,and CA724 were lower in the observation group than in the control group at_(2) years after treatment,with significant difference(t_(1)=30.239,P_(1)<0.001;t_(2)=33.416,P_(2)<0.001;t_(3)=23.569,P_(3)<0.001;t_(4)=12.203,P_(4)<0.001).Conclusion:The application of radical surgical resection has an exact effect in lung metastases of colorectal cancer,which can not only improve the survival rate,but also reduce the level of serum tumor markers,and is worthy of reference.

关 键 词：根治性手术切除 结直肠癌 肺转移灶 临床疗效 预后效果 血清肿瘤标志物 

分 类 号：R735.37[医药卫生—肿瘤]