喉部分切除术与全喉切除术对喉鳞状细胞癌患者外周血循环肿瘤细胞变化的影响  

Effects of partial laryngectomy and total laryngectomy on changes of peripheral blood circulating tumor cells in patients with laryngeal squamous cell carcinoma

作　　者：张晨煜 万玉峰[1] 赵益[2] 刘龙生[1] 高俊康 Zhang Chenyu;Wan Yufeng;Zhao Yi;Liu Longsheng;Gao Junkang(Department of Otorhinolaryngology,Head and Neck Surgery,Chaohu Hospital,Anhui Medical University,Hefei 238000,China;Department of Otorhinolaryngology Head and Neck Surgery,First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学附属巢湖医院耳鼻咽喉头颈外科,合肥238000 [2]安徽医科大学第一附属医院耳鼻咽喉头颈外科,合肥230022

出　　处：《中华实验外科杂志》2021年第11期2258-2261,共4页Chinese Journal of Experimental Surgery

基　　金：安徽省高校自然科学基金项目(KJ2019A0260);2020年度安徽医科大学校科研基金项目(2020xkj220)。

摘　　要：目的探讨喉部分切除术与全喉切除术对喉鳞状细胞癌(LSCC)患者外周血循环肿瘤细胞(CTC)变化的影响以及与患者预后的关联。方法选取安徽医科大学第一附属医院耳鼻喉头颈外科2019年5月至2020年5月收住入院拟行手术治疗的喉恶性肿瘤患者,共计86例。根据手术方式不同将其分成喉部分切除术组(44例)以及全喉切除术组(42例),比较两组术中、术后指标,并对手术治疗后的患者进行为期一年以上的随访,记录肿瘤复发和转移率,术前2 d与术后2 d检测患者外周血CTC水平,分析CTC水平与术后患者预后和肿瘤复发转移的关系。计数资料比较采用χ^(2)检验,计量资料比较采用t检验,相关分析采用Pearson相关分析。结果两组术后外周血CTC指标高于两组术前[(14.10±2.07)、(15.26±2.93) FU/3 ml比(9.52±1.56)、(9.91±2.05) FU/3 ml,t=16.817、16.110,P<0.05]。全喉切除术组术后2 d外周血CTC指标高于喉部分切除术组[(15.26±2.93) FU/3 ml比(14.10±2.07) FU/3 ml,t=2.402,P<0.05]。术后2 d外周血CTC水平与随访1年以上肿瘤复发转移呈正相关(rs=0.464,P<0.05)。结论全喉切除术与喉部分切除术比较导致外周血CTC水平升高更多。外周血CTC水平与肿瘤复发转移呈正相关,外周血CTC水平可作为LSCC患者术后预后的参考指标。Objective To investigate the effect of partial laryngectomy and total laryngectomy on circulating tumor cell(CTC)changes in peripheral blood circulation in patients with laryngeal squamous cell carcinoma(LSCC)and its correlation with prognosis.Methods The experimental subjects were 86 patients with laryngeal malignant tumor who were admitted to the department of otolaryngology,head and neck surgery from May 2019 to May 2020 and planned to receive surgical treatment.According to different surgical methods,the patients were divided into partial laryngectomy group(44 cases)and total laryngectomy group(42 cases).To compare intraoperative and postoperative indexes of the two groups,and patients were followed up for more than one year after surgical treatment,to record tumor recurrence and metastasis rates and peripheral blood CTC levels of the patients were detected 2 days before surgery and 2 days after surgery,and to analyze relationship between CTC level and postoperative prognosis and tumor recurrence and metastasis.The count data were compared by 2 test.T test was used to compare measurement data.Pearson correlation analysis was used for correlation analysis.Results The CTC index of peripheral blood in the two groups after operation was higher than that before operation[(14.10±2.07),(15.26±2.93)FU/3 ml than(9.52±1.56),(9.91±2.05)FU/3 ml,t=16.817,16.110,P<0.05].The CTC index of peripheral blood in total laryngectomy group was higher than that in partial laryngectomy group[(15.26±2.93)FU/3 ml than(14.10±2.07)FU/3 ml,t=2.402,P<0.05].There was a positive correlation between CTC level in peripheral blood 2 days after operation and tumor recurrence and metastasis after 1 year follow-up(rs=0.464,P<0.05).Conclusion Total laryngectomy can increase the level of CTC in peripheral blood more than partial laryngectomy.The level of CTC in peripheral blood is positively correlated with tumor recurrence and metastasis.The level of CTC in peripheral blood can be used as a reference index for postoperative prognosis of patie

关 键 词：喉鳞状细胞癌 喉部分切除术 全喉切除术 循环肿瘤细胞 

分 类 号：R739.65[医药卫生—肿瘤]