血清VEGF、PDGF和ES水平与湿性年龄相关性黄斑变性的关系  

Relationship between the levels of serum VEGF,PDGF and ES and wet age-related macular degeneration

作　　者：解鹏亮 郑陆芳 董明霞[1] 董如娇[1] 陈芳[1] XIE Pengliang;ZHENG Lufang;DONG Mingxia;DONG Rujiao;CHEN Fang(Tangshan Eye Hospital,Tangshan,Hebei,China,063000)

机构地区：[1]唐山市眼科医院,河北唐山063000

出　　处：《分子诊断与治疗杂志》2021年第10期1631-1634,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河北省重点科技研究计划项目(20181325)。

摘　　要：目的探究血清血管内皮生长因子(VEGF)、血小板衍生生长因子(PDGF)和内皮抑素(ES)水平与湿性年龄相关性黄斑变性(AMD)的关系。方法选择本院2019年10月至2020年10月收治的78例湿性AMD患者(病例组)和40例健康人群(对照组),采用酶联免疫吸附法检测VEGF、PDGF、ES水平,分析各指标与湿性AMD分期的关系,并绘制受试者工作特征曲线(ROC曲线)评价各指标的诊断效能。结果病例组血清VEGF、PDGF水平高于对照组,ES水平低于对照组,差异均有统计学意义(P<0.05)。病例组血清VEGF、PDGF水平:晚期>中期>早期,ES水平:晚期>中期>早期,两两比较差异均有统计学意义(P<0.05)。AMD患者血清VEGF水平与PDGF水平呈正相关(P<0.05),而血清VEGF和PDGF水平均与ES水平无关(P>0.05)。AMD患者VEGF、PDGF水平与病情分期呈正相关(P<0.05),ES水平与病情分期呈负相关(P<0.05)。VEGF、PDGF、ES水平诊断AMD的曲线下面积为0.868、0.833、0.694,诊断AMD中晚期的曲线下面积为0.945、0.874、0902。结论VEGF、PDGF、ES水平均与湿性AMD的发生密切相关,可作为湿性AMD潜在的诊断检测指标。Objective To explore the relationship between the levels of serum vascular endothelial growth factor(VEGF),platelet-derived growth factor(PDGF)and endostatin(ES)and wet age-related macular degeneration(AMD).Methods 78 patients with wet AMD(case group)and 40 healthy people(control group)in the hospital were selected from October 2019 to October 2020.Enzyme-linked immunosorbent assay was used to detect the levels of VEGF,PDGF and ES in the two groups,and the relationship between each indicator and wet AMD staging was analyzed.Receiver operating characteristic curve(ROC curve)was drawn to evaluate the diagnostic efficacy of indicator.Results The levels of serum VEGF and PDGF in the case group were higher than those in the control group,and the level of ES was lower than that in the control group(P<0.05).The levels of serum VEGF and PDGF in the case group:advanced stage>middle stage>early stage,and the level of ES:advanced stage>middle stage>early stage,with statistical significance in pairwise comparison(P<0.05).Serum VEGF levels in AMD patients were positively correlated with PDGF levels(P<0.05),while serum VEGF and PDGF levels were not related to ES levels(P>0.05).The levels of VEGF and PDGF in AMD patients were positively correlated with the stage of the disease(P<0.05),and ES levels were negatively correlated with the stage of the disease(P<0.05).The area under the curve for diagnosis of AMD by VEGF,PDGF,and ES levels were 0.868,0.833,0.694,and the area under the curve for diagnosis of ad-vanced AMD was 0.945,0.874,and 0902.Conclusion The levels of VEGF,PDGF,and ES are closely related to the occurrence of wet AMD,and can be used as potential diagnostic testing indicators for wet AMD.

关 键 词：VEGF PDGF ES 湿性年龄相关性黄斑病变 

分 类 号：R774.5[医药卫生—眼科]