血清和粪便CEA、CA199、AFP辅助诊断结直肠癌的研究  

Serum and fecal CEA,CA199,AFP for the diagnosis of colorectal cancer

作　　者：唐阳[1] 贾逸文 彭琼[1] TANG Yang;JIA Yiwen;PENG Qiong(Department of Gastroenterology,Hefei First People's Hospital,Hefei,Anhui,China,230000)

机构地区：[1]合肥市第一人民医院消化内科,安徽合肥230000

出　　处：《分子诊断与治疗杂志》2021年第10期1665-1668,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省合肥市卫生计生应用医学科研项目(hwk2018zd008)。

摘　　要：目的探讨粪便癌胚抗原(CEA)、糖类抗原199(CA199)、甲胎蛋白(AFP)对结直肠癌的诊断效能。方法选取2017年1月至2021年3月本院收治的132例结直肠癌患者(结直肠癌组)、50例结直肠息肉患者(息肉组)、50例肠镜检查未见异常的住院患者(对照组),比较各组外周血和粪便CEA、CA199、AFP水平,应用受试者工作特征曲线(ROC)及ROC下面积(AUC)分析外周血和粪便各指标诊断结直肠癌的效能,并比较粪便不同CEA、CA199、AFP水平者结直肠癌发生率。结果外周血CEA、CA199水平比较:结直肠癌组>息肉组>对照组,差异有统计学意义(P<0.05);结直肠癌组外周血AFP高于息肉组、对照组,差异有统计学意义(P<0.05);粪便CEA、CA199、AFP:结直肠癌组>息肉组>对照组,差异有统计学意义(P<0.05);与外周血各指标相比,粪便各指标诊断结直肠癌的AUC较大(P<0.05);外周血各指标联合、粪便各指标联合诊断结直肠癌的AUC大于对应标本单一指标,且粪便各指标联合的AUC大于外周血各指标联合的AUC(P<0.05);CEA、CA199、AFP高水平者结直肠癌发生率高于低水平者(P<0.05)。结论结直肠癌、结直肠息肉、健康对照人群粪便与外周血CEA、CA199、AFP具有相同的变化趋势,粪便CEA、CA199、AFP诊断结直肠癌的价值更高,可作为结直肠癌的无创性检查项目。Objective To investigate the diagnostic efficacy of fecal carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),and alpha-fetoprotein(AFP)for colorectal cancer.Methods From January 2017 to March 2021,132 patients with colorectal cancer(colorectal cancer group),50 patients with colorectal polyps(polyp group),and 50 hospitalized patients with no abnormalities in colonoscopy(Control group)were selected.The levels of CEA,CA199,and AFP in peripheral blood and feces in each group were compared.Receiver operating characteristic curve(ROC)and area under ROC(AUC)were used to analyze the efficacy of peripheral blood and feces in the diagnosis of colorectal cancer,and to compare the incidence of colorectal cancer in feces with different levels of CEA,CA199,and AFP.Results The peripheral blood CEA and CA199 levelsin the colorectal cancer group were higher than those in the polyp group and the control group.The peripheral blood CEA and CA199 in the polyp group were higher than those in the control group(P<0.05).The peripheral blood AFP in the colorectal cancer group was higher than that in the polyp group and the control group(P<0.05).Fecal CEA,CA199,and AFP levels in the colorectal cancer group were higher than those in the polyp group and the control group,and the fecal CEA,CA199,and AFP in the polyp group were higher than those in the control group(P<0.05).Compared with the indicators of peripheral blood,the AUC of fecal indicators for the diagnosis of colorectal cancer is larger.The AUC of the combineddiagnosis of colorectal cancer by the combination of peripheral blood indicators and the combined fecal indicators is greater than the single indicator of the corresponding specimen,and the combined AUC of the fecal indicators is greater than the combined AUC of the peripheral blood indicators;The incidence of colorectal cancer in patients with high levels of CEA,CA199 and AFP was higher than that of patients with low levels(P<0.05).Conclusion Colorectal cancer,colorectal polyps,and healthy controls have the same tre

关 键 词：粪便 CEA CA199 AFP 结直肠癌 

分 类 号：R735.34[医药卫生—肿瘤]