卵巢癌患者癌组织中nm23-H1和N-cad的表达及临床意义  

Expression and clinical significance of nm23-H1 and N-cad in cancer tissues of patients with ovarian cancer

作　　者：章琴[1] 黄庆 ZHANG Qin;HUANG Qing(Department of Obstetrics and Gynecology,First People's Hospital of Jingzhou,Jingzhou,Hubei,China,434000;Department of Obstetrics and Gynecology,Wuhan Asia Heart Disease General Hospital,Wuhan,Hubei,China,430022)

机构地区：[1]荆州市第一人民医院妇产科,湖北荆州434000 [2]武汉亚洲心脏病总医院妇产科,湖北武汉430022

出　　处：《分子诊断与治疗杂志》2021年第10期1705-1708,共4页Journal of Molecular Diagnostics and Therapy

基　　金：湖北省自然科学基金(2018CBD0173)。

摘　　要：目的探讨卵巢癌患者癌组织中第23株被检测的基因H1(nm23-H1)蛋白、神经型钙粘附蛋白(N-cad)表达及其临床意义。方法采用免疫组化法检测2011年1月至2013年12月间采集的118例卵巢癌患者组织中nm23-H1、N-cad表达情况。分析nm23-H1、N-cad表达阳性率与卵巢癌病理分级、淋巴结转移间的关系;比较临床病理特征之间的nm23-H1、N-cad表达差异和两组间的生存率。结果转移者nm23-H1表达阳性率低于无转移组(P<0.05)、N-cad表达阳性率高于无转移组(P<0.05);nm23-H1低表达组较高表达组浆液型腺癌比例高、病理分级中Ⅲ级比例高、FIGO分期中Ⅲ~Ⅳ比例高(P<0.05)。N-cad低表达组病理分级中Ⅲ级比例低、FIGO分期中Ⅲ~Ⅳ比例低(P<0.05);nm23-H1低表达组3年生存率低于高表达组(P<0.05),N-cad低表达组3年生存率高于高表达组(P<0.05)。结论卵巢癌组织中的nm23-H1及N-cad表达与卵巢癌发生进展相关,从而可影响卵巢癌患者的生存期。Objective To explore the expressions and clinical significance of nm23-H1 protein and N-cadherin(N-cad)in cancer tissues of patients with ovarian cancer.Methods Immunohistochemistry was used to detect the expressions of nm23-H1 and N-cad in cancer tissues of 118 patients with ovarian cancer collected from January 2011 to December 2013.The relationship between positive expression rates of nm23-H1 and N-cad and pathological grade and lymph node metastasis of ovarian cancer was analyzed.The expressions of nm23-H1 and N-cad among clinicopathological features and the survival rate between the two groups were compared.Results The positive rate of nm23-H1 expression in metastasis group was lower than that in nonmetastasis group(P<0.05)while the positive rate of N-cad expression was higher than that in non-metastasis group(P<0.05).The proportion of serous adenocarcinoma was higher,the proportion of gradeⅢin pathological grade was higher and the proportion ofⅢ~Ⅳin FIGO stage was higher in nm23-H1 low expression group compared with nm23-H1 high expression group(P<0.05).The proportion of gradeⅢin pathological grade was lower and the proportion ofⅢ~Ⅳin FIGO stage was lower in N-cad low expression group(P<0.05).The 3-year survival rate in nm23-H1 low expression group was lower than that in high expression group(P<0.05)while the 3-year survival rate in N-cad low expression group was higher than that in high expression group(P<0.05).Conclusion The expressions of nm23-H1 and N-cad in ovarian cancer tissues are related to the occur-rence and progression of ovarian cancer,thus affecting the survival time of patients with ovarian cancer.

关 键 词：卵巢癌 蛋白表达 NM23-H1 神经型钙粘附蛋白 

分 类 号：R737.31[医药卫生—肿瘤]