Globo H抗原与乳腺癌免疫治疗的研究进展  

Progression of Globo H antigen with immunotherapy in breast cancer

作　　者：张静怡 樊英 ZHANG Jingyi;FAN Ying(Department of Medical Oncology, National Cancer Center. Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China)

机构地区：[1]国家癌症中心中国医学科学院北京协和医学院肿瘤医院内科,北京100021 [2]国家肿瘤临床医学研究中心,100021

出　　处：《临床肿瘤学杂志》2021年第10期942-946,共5页Chinese Clinical Oncology

摘　　要：肿瘤相关糖抗原(tumor-associated carbohydrate antigens,TACAs)在肿瘤细胞的转移以及信号转导方面起着重要的作用,Globo H抗原作为肿瘤细胞膜表面重要的TACAs,是肿瘤免疫治疗的理想靶标,其表达水平与肿瘤患者预后相关。Globo H抗肿瘤疫苗在乳腺癌主动免疫治疗中已开展了一系列研究。本文将对Globo H与乳腺癌免疫治疗的相关研究做一综述。Tumor-associated carbohydrate antigens(TACAs)play key roles in tumor cell metastasis and signal transduction.Globo H antigen,as an important member of TACAs family on the surface of tumor cell membranes,is an ideal target moleculefor cancer immunotherapy.Its expressionis associated with poorer prognosis of cancer patients.There have been a series of studies about active immunotherapywithGloboH cancer vaccinein breast cancer.Here,we reviewed the current studies on Globo H and elucidated the effect on immunotherapy in breast cancer.

关 键 词：乳腺癌 肿瘤相关糖抗原 免疫治疗 

分 类 号：R737.9[医药卫生—肿瘤]