超声热疗联合TPF化疗治疗19例老年晚期口腔鳞癌的疗效分析  

Analysis of curative effect of ultrasonic hyperthermia combined with TPF chemotherapy on 19 elderly with advanced oral squamous cell carcinoma

作　　者：李蕾 李晓东 庄乾伟[2] 葛良玉[2] 李志萍[2] 顾倩平[2] 白玉婷 孟箭 LI Xiao-dong;ZHUANG Qian-wei;GE Liang-yu;LI Zhi-ping;GU Qian-ping;BAI Yu-ting;MENG Jian(School of Stomalology,Weifang Medical University,Weifang 261053,Shandong Province;Department of Stomatology,Xuzhou Central Hospital,Xuzhou 221000,Jiangsu Province,China)

机构地区：[1]潍坊医学院口腔医学院,山东潍坊261053 [2]徐州市中心医院口腔科,江苏徐州221000

出　　处：《上海口腔医学》2021年第5期543-547,共5页Shanghai Journal of Stomatology

基　　金：徐州市重点研发计划(20210230);江苏省卫生计生委科研课题(H2017080);徐州市科技重点研发计划(KC17196)。

摘　　要：目的:观察超声热疗联合TPF化疗对老年晚期口腔鳞状细胞癌(OSCC)的疗效及安全性。方法:对2017年1月—2020年1月在徐州市中心医院口腔科就诊的19例OSCC老年患者,给予TPF化疗,周期第1天—多西他赛(75 mg/m^(2))+顺铂(75 mg/m^(2)),周期第1~5天—5,Fu(750 mg/m^(2));在化疗过程中做5次热疗,分别于化疗开始的第1、3、5、7、9天,超声热化疗共2个疗程,观察并评价效果。采用SPSS 20.0软件包进行统计学分析,利用Kaplan-Meire法计算生存率。结果:根据实体瘤评价标准1.0版,对肿瘤的变化进行疗效评价,其中完全缓解3例,部分缓解10例,疾病稳定5例,疾病进展1例,总有效率为68.4%。中位随访时间为36个月(8~48个月),2年内生存率为63.2%。不良反应主要表现为常规化疗反应,未见严重不良反应。结论:超声热疗联合化疗对老年口腔鳞癌患者具有协同抗肿瘤作用,安全有效,有望成为肿瘤治疗的又一种选择。PURPOSE:To evaluate the efficacy and safety of ultrasound hyperthermia combined with TPF chemotherapy for advanced oral squamous cell carcinoma in the elderly.METHODS:Nineteen elderly patients who had definite pathological diagnosis were enrolled in this clinical trail from June 2017 to January 2020.Docetaxel(75 mg/m^(2))+cisplatin(75 mg/m^(2))were given on the 1 st day,and 5,Fu(750 mg/m^(2))on the 1 st to 5 th day of the cycle.Five times of hyperthermia were performed in the course of chemotherapy,respectively on the l,3,5,7 and 9 days after the beginning of chemother-apy.All patients received 2 cycles of thermo-chemotherapy.Statistical analysis was performed using SPSS 20.0 software package.Kaplan-Meire method was used to calculate survival rate.RESULTS:According to the efficacy evaluation standard for solid tumor(version 1.0),complete response(CR)was seen in 3 cases,partial response(PR)was seen in 10 cases,stable disease(SD)was seen in 5 cases,progressive disease(PD)was seen in 1 case.The overall responding rate was68.4%.The median follow-up time was 36 months(8-48 months),and the 2-year overall survival rates were 63.2%.No serious adverse reactions were observed.CONCLUSIONS:Ultrasound hyperthermic therapy combined with chemotherapy has a synergistic anti-tumor effect on patients with advanced oral squamous cell carcinoma,which is safe and effective,and is worthy of becoming another choice of tumor treatment.

关 键 词：超声热疗 化疗 口腔鳞癌 老年 

分 类 号：R739.8[医药卫生—肿瘤]