PLA-PEG复合膜材微泡的制备  

Preparation of PLA-PEG Composite Microbubbles

作　　者：朱明月 高宝晴 周淑晶[1] 陈欣梦 张杰[1] ZHU Ming-yue;GAO Bao-qing;ZHOU Shu-jing;CHENG Xin-meng;ZHANG Jie(School of Pharmacy,Jiamusi University,Jiamusi 154007,China)

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《精细化工中间体》2021年第4期37-39,47,共4页Fine Chemical Intermediates

基　　金：黑龙江省自然科学基金项目(LH2021H110);黑龙江省省属本科高校基本科研业务费优秀创新团队建设项目(2018-KYYWF-0914);黑龙江省大学生创新创业训练计划项目(202010222053)。

摘　　要：采用双乳化溶剂挥发法制备PLA-PEG复合膜材的微泡,以微泡粒径为指标,优化微泡制备参数。实验结果表明,在聚乳酸(PLA)用量0.3 g、聚乙二醇(PEG)用量0.3 g、1次超声功率700 W、2次超声功率800 W、聚乙烯醇(PVA)用量为50 mL、浓度为1%、异丙醇浓度5%的条件下,所制备的PLA-PEG微泡的平均粒径为508.7 nm,Zeta电位-30.6 mV,微泡呈规则圆形且表面光滑。PLA-PEG composite microbubble was prepared by the double emulsion solvent evaporation method.With microbubble particle size as an index,the preparation parameters of microbubbles were optimized.Experimental results showed that the average particle size of the prepared PLA-PEG microbubbles was of508.7 nm and Zeta potential was-30.6 m V under the conditions of PLA of 0.3 g,PEG of 0.3 g,primary ultrasonic power of 700 W,secondary ultrasonic power of 800 W,PVA of 50 mL at a concentration of 1%,and isopropanol of 5%.PLA-PEG composite microbubbles were regular round with a smooth surface.

关 键 词：微泡 聚乳酸 聚乙二醇 

分 类 号：TQ317[化学工程—高聚物工业]