^(131)Ⅰ治疗对甲状腺乳头状癌外周血淋巴细胞染色体畸变率和甲状腺球蛋白抗体的影响  

Effects of ^(131)Ⅰ on chromosome aberrations in peripheral blood lymphocytes and thyroglobulin antibodies in patients with papillary thyroid carcinoma

作　　者：冯丽 张静 张萍 FENG Li;ZHANG Jing;ZHANG Ping(Department of Endocrinology,Baoji High-tech Hospital,Baoji 721006,China)

机构地区：[1]陕西省宝鸡高新医院内分泌科,宝鸡721006

出　　处：《中国肿瘤临床与康复》2021年第10期1189-1192,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨131Ⅰ治疗对甲状腺乳头状癌(PTC)患者外周血淋巴细胞染色体畸变率(CAR)和甲状腺球蛋白抗体(Tg Ab)变化的影响。方法选取2020年1月至2020年12月间宝鸡高新医院接受治疗的62例PTC患者作为研究对象,并根据131Ⅰ的剂量分为高剂量组(26例)和低剂量组(36例),分析131Ⅰ治疗效果以及不同剂量治疗前1d、治疗后5d、治疗后1个月和治疗6个月后外周血淋巴细胞CAR和Tg Ab的变化情况。结果62例患者经131Ⅰ治疗后,完全治愈4例(6.5%),好转30例(48.4%),无效28例(45.2%),临床总有效率为54.8%,临床无效率为45.2%。治疗后5d的CAR和Tg水平高于治疗后1个月,治疗后1个月后的CAR和Tg水平高于治疗前1d和治疗后6个月;治疗后5d的微核率(MNR)水平高于治疗后1个月,治疗后1个月的MNR水平高于治疗后6个月,治疗后6个月的MNR水平高于治疗前1d;治疗后6个月的Tg Ab水平低于治疗后1个月,治疗后1个月的Tg Ab水平低于治疗后5d,治疗后5d的Tg Ab水平低于治疗前1d,差异均有统计学意义(均P<0.05)。高剂量组治疗后5d、治疗后1个月、治疗后6个月CAR水平高于低剂量组,高剂量组治疗后5d、治疗后1个月和治疗后6个月的Tg Ab水平低于低剂量组,差异均有统计学意义(均P<0.05)。结论131Ⅰ治疗对PTC患者可导致外周血淋巴细胞CAR增大,且剂量越大,CAR增大越明显,但这种增大是暂时性,可随着时间的延长逐渐恢复;Tg Ab在131Ⅰ治疗后显著降低,且131Ⅰ剂量越高降低越明显。Objective To explore the effect of^(131)Ⅰ on changes in chromosome aberration rate(CAR)and thyroglobulin antibodies(Tg Ab)in peripheral blood lymphocytes in patients with papillary thy-roid carcinoma(PTC).Methods Sixty-two PTC patients admitted to Baoji High-tech Hospital were select-ed from January 2020 to December 2020.They were divided into a high dose group(26 patients)and a low dose group(36 patients)according to the dosage of131Ⅰ.The therapeutic effect of131Ⅰ and the changes in CAR and Tg Ab in peripheral blood lymphocytes with different doses of^(131)Ⅰ were analyzed at 1 d before the treatment,5 d after the treatment,1 month after the treatment and 6 months after the treatment.Results After^(131)Ⅰ treatment,4 patients(6.5%)were completely cured,condition was improved in 30 patients(48.4%),and the treatment was ineffective in 28 patients(45.2%).The overall clinical efficacy was 54.8%.The levels of CAR and Tg were significantly higher at 5 d after the treatment than at 1 month after the treatment,and higher at 1 month after the treatment than at 1 d before the treatment and 6 months after the treatment(all P<0.05).The levels of micronucleus rate(MNR)were significantly higher at 5 d after the treatment than at 1 month after the treatment,higher at 1 month after the treatment than at 6 months after the treatment and higher at 6 months after the treatment than at 1 d before the treatment.The levels of Tg Ab were significantly lower at 6 months after the treatment than at 1 month after the treatment,lower at 1 month after the treatment than at 5 d after the treatment and lower at 5 d after the treatment than at 1 d after the treatment(all P<0.05).The CAR levels were significantly higher in the high dose group than in the low dose group at 5 d,1 month and 6 months after the treatment(all P<0.05).Tg Ab levels were lower in the high dose group than in the low dose group at 5 d,1 month and 6 months after the treatment(all P<0.05).TGAb levels in high-dose group were significantly lower than those in low-dos

关 键 词：^(131)Ⅰ 甲状腺乳头状肿瘤 染色体畸变率 甲状腺球蛋白抗体 

分 类 号：R736.1[医药卫生—肿瘤]