基于酶活性的抑菌作用研究进展  

Research Progress of Antibacterial Action Based on Enzyme Activity

作　　者：邓欣彤 胡婕妤 刘玲丽 朱韵琪 周雨蝶 陈焱婷 王欣 白雪莲[1] DENG Xintong;HU Jieyu;LIU Lingli;ZHU Yunqi;ZHOU Yudie;CHEN Yanting;WANG Xin;BAI Xuelian(College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China)

机构地区：[1]杭州师范大学生命与环境科学学院,浙江杭州311121

出　　处：《农产品加工》2021年第20期68-72,共5页Farm Products Processing

基　　金：国家级大学生创新创业训练计划项目(202010346053);杭州师范大学本科生创新能力提升工程项目(CX2019204,CX2019205,CX2019198,CX2020121);杭州师范大学恒逸邱建林星光奖学科竞赛项目(X2019051517)。

摘　　要：病原菌入侵宿主,产生致病物质,造成宿主感染。酶催化着生物的新陈代谢、营养物质和能量转换等许多化学反应过程,而酶活性的有序性一旦遭到破坏,会导致代谢紊乱,产生疾病,甚至死亡。抑菌物质可作用于酶,从而影响活性,进而发挥抑菌作用。因此,可基于酶活性的变化进行抑菌研究。根据国内外抑菌作用研究结果,对细胞壁、细胞膜、体内代谢、遗传物质转录等相关酶的抑菌机理研究进行概述,为后续相关研究提供参考。Pathogenic microorganisms invade the host and produce pathogenic substances,causing host infection.Enzymes catalyze many chemical reaction processes such as metabolism,nutrient and energy conversion of organisms.Once the order of enzyme activity was destroyed,metabolic disorders,diseases and even death will result.Antimicrobial substances can act on enzymes,thereby affecting their activity and thus exerting their bacteriostatic effect.Therefore,antibacterial research can be carried out based on the change of enzyme activity.Based on the research results of antibacterial action at home and abroad,this paper summarized the antibacterial mechanism of related enzymes in cell wall,cell membrane,metabolism in vivo and transcription of genetic material,so as to provide reference for the follow-up research.

关 键 词：抑菌作用 几丁质酶 合成代谢酶 分解代谢酶 氧化还原代谢酶 

分 类 号：Q556[生物学—生物化学]