特利加压素联合奥美拉唑治疗肝硬化上消化道出血的临床研究 及止血效果分析  

Clinical study and analysis of hemostatic effect of terlipressin combined with omeprazole in the treatment of upper gastrointestinal bleeding in liver cirrhosis

作　　者：黄洁[1] 童轶[2] Huang Jie;Tong Yi(Outpatient Department of Internal Medicine,the People's Hospital of Tongcheng County,Hubei Xianning 437400;Emergency Room,the People's Hospital of Tongcheng County,Hubei Xianning 437400)

机构地区：[1]通城县人民医院门诊内科,湖北咸宁437400 [2]通城县人民医院急诊室,湖北咸宁437400

出　　处：《中国社区医师》2021年第32期39-40,共2页Chinese Community Doctors

摘　　要：目的:评价特利加压素联合奥美拉唑治疗肝硬化上消化道出血的临床价值。方法:2017年3月-2020年3月收治肝硬化上消化道出血患者82例,随机分为两组,各41例。对照组接受奥美拉唑注射治疗;观察组运用特利加压素联合奥美拉唑治疗。比较两组治疗效果。结果:观察组止血时间短于对照组,输血量低于对照组,差异均有统计学意义(P<0.05);观察组24 h止血率高于对照组,48 h再出血率低于对照组,差异均有统计学意义(P<0.05);观察组治疗后C反应蛋白(CRP)、一氧化氮(NO)水平低于对照组,差异有统计学意义(P<0.05);观察组住院时间短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肝硬化上消化道出血患者应用特利加压素联合奥美拉唑治疗的效果确切,有助于提高止血效果。Objective:To evaluate the clinical value of terlipressin combined with omeprazole in the treatment of upper gastrointestinal bleeding in liver cirrhosis.Methods:From March 2017 to March 2020,82 patients with upper gastrointestinal bleeding from cirrhosis were selected,they were randomly divided into the two groups with 41 cases in each group.The control group received omeprazole injection.The observation group was treated with terlipressin combined with omeprazole.We compared the treatment effects of the two groups.Results:The hemostasis time of the observation group was shorter than that of the control group,and the amount of blood transfusion was lower than that of the control group,the differences were statistically significant(P<0.05).The 24-hour hemostatic rate in the observation group was higher than that in the control group,and the 48-hour rebleeding rate was lower than that in the control group,the differences were statistically significant(P<0.05).The CRP and NO levels in the observation group were lower than those in the control group after treatment,the difference was statistically significant(P<0.05).The hospital stay in the observation group was shorter than that in the control group,the difference was statistically significant significance(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The effect of terlipressin combined with omeprazole in patients with upper gastrointestinal bleeding in liver cirrhosis is definite,which helps to improve the hemostatic effect.

关 键 词：奥美拉唑 特利加压素 肝硬化 上消化道出血 

分 类 号：R575.2[医药卫生—消化系统]