Natural products against HIV latency  

天然产物抗击潜伏期艾滋病毒

作　　者：Kouharu Otsuki Mi Zhang Wei Li 张米;李巍(东邦大学药学部,日本千叶县船桥市三山2-2-1)

机构地区：[1]Faculty of Pharmaceutical Sciences,Toho University,Miyama 2-2-1,Funabashi,Chiba,Japan

出　　处：《Acupuncture and Herbal Medicine》2021年第1期10-21,共12页针灸和草药（英文）

基　　金：supported by the Japan Society for the Promotion of Science KAKENHI 17K08348 and 21K06619(Wei Li).

摘　　要：Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to reactivation.Therefore,the development of new treatment methods aimed at a complete cure for HIV is needed.The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir cells.Many LRAs can be obtained from natural resources,including plants and marine organisms.In this review,we provide an overview of natural products used to eliminate HIV latency.抗逆转录病毒疗法在抑制人类免疫缺陷病毒(HIV)复制以及将艾滋病毒感染从致命疾病转变为可控慢性病方面取得了巨大成功。然而,潜伏期HIV仍继续存在于感染者体内并可能再次活化。因此,急需研发根除艾滋病毒的新疗法。目前,一种基于清除和防止潜伏期病毒再活化的“激活与杀灭”的疗法是根除艾滋病毒的领先策略。该策略使用潜伏期感染激活剂(LRAs)激活潜伏期艾滋病毒库中的HIV前病毒。多数LRAs可从天然的植物和海洋生物资源中获取。本综述中概述了有望用于根除潜伏期艾滋病毒的天然产物。

关 键 词：DITERPENOID Human immunodeficiency virus Human immunodeficiency virus latency Shock and kill THYMELAEACEAE 

分 类 号：R51[医药卫生—内科学]