3D打印模板联合CT引导^(125)I粒子植入治疗骨转移癌术前术后剂量学评价  

Dosimetry verfication between pre and post operation of 3D-printing template assisted by CT-guided ^(125)I seed implantation in the treatment of bone metastases

作　　者：李洪均[1] 刘娜[1] 张建萍[1] 于鸿煦 刘雪辉[1] 王俊杰[2] Li Hongjun;Liu Na;Zhang Jianping;Yu Hongxu;Liu Xuehui;Wang Junjie(Department of Nuclear Medicine,Tianjin Third Central Hospital,Tianjin 300170,China;Department of Radiation Oncology,Third Hospital Peking University,Beijing 100191,China)

机构地区：[1]天津市第三中心医院核医学科,300170 [2]北京大学第三医院肿瘤治疗中心放疗科,100191

出　　处：《中华放射医学与防护杂志》2021年第10期735-740,共6页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的对比分析3D打印模板联合CT引导^(125)I粒子植入治疗骨转移癌术前术后常用剂量学指标差异,指导临床应用。方法对2019年6月至2021年1月天津市第三中心医院骨转移癌粒子植入手术的10例患者共12个病灶进行回顾性分析,12个病灶均采用3D打印模板引导粒子植入,处方剂量120~140 Gy,比较术前治疗计划及术后验证计划中常用剂量学指标差异,包括D90、D100、V90、V100、V150以及术前计划粒子数量和术后实际使用粒子数量,采用配对t检验对术前术后剂量参数进行对比分析。结果术前和术后D90、D100、V90、V100、V150等剂量学指标差异均无统计学意义(P>0.05),术后实际使用粒子数量多于术前计划,差异有统计学意义(t=-2.930,P<0.05)。结论3D打印模板联合CT引导^(125)I粒子植入治疗骨转移癌,剂量精准,可达到术前计划要求,应积极推广临床使用。Objective To compare and analyze the differences of common dose indicators before and after operation of 3D-printing template assisted by CT-guided ^(125)I seed implantation in the treatment of bone metastases to guide clinical application.Methods A retrospective analysis of 12 lesions in the 10 patients(9 males and 1 female,median age 65 years),who underwent seed implantation surgery for bone metastases in the Tianjin Third Central Hospital from June 2019 to January 2021,was conducted.All the lesions were adopted for 3D-printing template to guide seed implantation and the prescribed dose was 120-140 Gy.The differences of common dose indicators between preoperative treatment plan and postoperative verification plan were compared,including D90(dose received by 90%of the target volume),D100(dose received by 100%of the target volume),V90(the volume percent for tumor target volume receiving 90%of the prescribed dose),V100(the volume percent for tumor target volume receiving 100%of the prescribed dose),V150(the volume percent for tumor target volume receiving 150%of the prescribed dose),as well as the quantity of seeds planned and actually used.The paired t-test was performed to compare and analyze those parameters.Results There was no statistically significant difference in pre-and postoperative D90,D100,V90,V100,V150(P>0.05).The actual quantity of seeds used after operation was more than that of the preoperative planned quantity and the difference was statistically significant(t=-2.930,P<0.05).Conclusions The clinical use of 3D-printing template assisted by CT-guided ^(125)I seed implantation for bone metastasis should be promoted since the dose is accurate and the requirements of preoperative plan can be achieved.

关 键 词：3D打印模板 放射性粒子植入 骨转移癌 近距离放疗 放射治疗剂量 

分 类 号：R738.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]