Research Progress on Pharmacology and adverse reactions of hirudin  

作　　者：Y u-Qiang Lu Guo-Cheng Zhang Hui Ding Zhao-Lin Shi Ru-Ying Li 

机构地区：[1]Shaanxi University of Chinese Medicine,Xianyang 712046,China [2]The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712046,China.

出　　处：《Asian Toxicology Research》2021年第3期18-26,共9页

摘　　要：Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hirudin derivatives such as lepirudin,desirudin and bivalirudin,and the third is new hirudin preparations such as hirudin-bovine serum albumin(BSA)nanoparticles,polydopamine fitted titanium dioxide nanoparticles systems and recombinant hirudins-2(rhv2)-loaded picmice.The pharmacological effects and adverse reactions of hirudin were reviewed to evaluate its safety,efficacy and quality control.Hirudin has obvious pharmacological effects on cardio-cerebrovascular diseases(coronary atherosclerotic heart disease,myocardial infarction,hyperlipidemia,cerebral infarction,arteriosclerosis obliterans of lower extremities),angiogenesis(fracture,skinflaptransplantation),tissue fibrosis,tumor,ophthalmopathy,hyperuricemia and female infertility.However,attention should be paid to clinical adverse reactions(bleeding,allergic reaction,infection,cutaneous pseudolymphoma).

关 键 词：HIRUDIN PHARMACOLOGY Clinical application Adverse reactions 

分 类 号：O62[理学—有机化学]