HIRUDIN

作品数：31被引量：90H指数：6
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相关作者：莫炜刘琳于敏陈华友齐向辉更多>>
相关机构：复旦大学浙江省人民医院南京大学河南大学更多>>
相关期刊：《Neural Regeneration Research》《World Journal of Clinical Cases》《Asian Journal of Pharmaceutical Sciences》《西南农业学报》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Inhibitory Effect of Hirudin on Hepatocellular Carcinoma Cells
《Agricultural Biotechnology》2024年第6期78-82,91,共6页Xintian HUANG Keyi ZHOU Dengfeng ZOU Jinfeng ZHOU Haijiao ZHANG Xiaofan WANG Jingyi JIANG Zhiqiang CHEN Changfu HU Xin JIANG 
Social Development Program of Guilin Science and Technology Bureau(20210227-9-3);Guangxi Medical and Health Appropriate Technology Development and Application Project(S2021057);School-level Undergraduate Innovation and Entrepreneurship Training Program(X2023106012040).
[Objectives]This study was conducted to explore the proliferation inhibition of hirudin on hepatocellular carcinoma HepG 2 cells and Huh-7 cells.[Methods]Hirudin solutions of different concentrations(2.0,2.5,3.0,3.5,4...
关键词：HIRUDIN HepG 2 cells and Huh-7 cells PROLIFERATION MIGRATION INHIBITION 
日本医蛭摄食前后不同组织中水蛭素基因(hirudin)的时空表达模式
《西南农业学报》2023年第7期1400-1405,共6页石萍 游华建 邓小书 陈仕江 鲁增辉 
重庆市基本科研业务费项目(cstc2019jxjl-jbky10009);重庆市中药研究院基本科研业务费项目(jbky20210031)。
【目的】探究日本医蛭在不同摄食阶段、各个组织(唾液腺、肠、嗉囊、皮肤及精/卵巢)中水蛭素基因(hirudin)的时空表达模式,为水蛭药材的科学合理利用提供理论依据。【方法】基于水蛭唾液腺转录组数据筛选结果及基因克隆获得的水蛭素基...
关键词：日本医蛭 水蛭素基因(hirudin) 摄食 时空表达模式 
Chemical protein synthesis elucidates key modulation mechanism of the tyrosine-O-sulfation in inducing strengthened inhibitory activity of hirudin
《Chinese Chemical Letters》2023年第5期213-216,共4页Ye Yang Mingchan Liang Rui Wang Chunmao He 
The financial support from the National Natural Science Foundation of China(Nos.91853117 and 22077036);the Natural Science Foundation of Guangdong Province(No.2020A1515010766)are greatly acknowledged。
Tyrosine sulfation is an important post-translational modification that enhances the inhibitory activity of hirudin.Herein,we developed a facile synthetic strategy to afford the sulfated hirudins with up to three modi...
关键词：Tyrosine sulfation HIRUDIN Chemical protein synthesis Post-translational modification Native chemical ligation 
Exploring the mechanism of hirudin in the treatment of diabetic kidney disease using network pharmacology combined with molecular docking verification被引量：1
《Journal of Traditional Chinese Medicine》2022年第4期586-594,共9页PANG Xinxin ZHU Qing PENG Zining ZHANG Yage SHI Xiujie HAN Jiarui 
Supported by the Natural Science Foundation of Henan Province(No.202300410256);the Research Project of the National TCM Clinical Research Base(No.2019JDZX2119);the Key R&D and Extension Project in Henan Province(No.202102310505,No.202102310171)
OBJECTIVE:To explore the mechanism of hirudin in the treatment of diabetic kidney disease(DKD).METHOD:Cytoscape software was used to analyze the network between hirudin targets and active components in the treatment o...
关键词：hirudins diabetic kidney disease network pharmacology molecular docking simulation 
Effect of Hirudin on farnesol X receptor pathway during acute intrahepatic cholestasis
《Gastroenterology & Hepatology Research》2022年第2期29-35,共7页Yu-qing Liu Yao Wang Wen-qian Tang Xin Cai Ren-wu Qin Lei Luo Fan Yang 
the 2017 Wuhan Science and Technology Bureau Project(2017060201010222).
Objective:The purpose of this study is to explore the effect of Hirudin on the farnesoid X receptor(FXR)pathway during acute intrahepatic cholestasis in vivo and in vitro.Method:In vivo,sixty male Sprague-Dawley rats ...
关键词：HIRUDIN (Z)-Guggulsterone α-isothiocyanate(ANIT) CHOLESTASIS FXR 
Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease被引量：3
《Asian Journal of Pharmaceutical Sciences》2022年第2期284-297,共14页Mengfang Wu Tian Xia Yaran Li Tianfa Wang Shijia Yang Jinchao Yu Qiaoyan Liang Teng Shen Min Yu Bing Zhao 
supported by the National Natural Science Foundation of China (NSFC 81902995);the project funded by China Postdoctoral Science Foundation (2018M641936)
Cardiovascular disease is the leading cause of global mortality,with anticoagulant therapy being the main prevention and treatment strategy.Recombinant hirudin(r-hirudin)is a direct thrombin inhibitor that can potenti...
关键词：ANTICOAGULANT r-hirudin Microneedle patch 3D printing technology 
Submucosal hematoma with a wide range of lesions, severe condition and atypical clinical symptoms: A case report
《World Journal of Clinical Cases》2021年第20期5683-5688,共6页Liang Liu Xing-Jie Shen Li-Jun Xue Shu-Kun Yao Jing-Yu Zhu 
Supported by Shandong Province Medical and Health Science and Technology Development Plan(Clinical Study of Minimally Invasive Treatment Under Endoscopy of Gastrointestinal Mucosa),No.2016WS0124.
BACKGROUND Submucosal hematoma(SH)is one of the rare causes of upper gastrointestinal bleeding.As a rare and critical disease in clinical practice,it should be paid more attention to by clinicians to avoid missed diag...
关键词：Submucosal hematoma HYPOPHARYNX lower esophagus hirudin and panax notoginseng powder GASTROSCOPY Computed tomography Case report 
Research Progress on Pharmacology and adverse reactions of hirudin
《Asian Toxicology Research》2021年第3期18-26,共9页Y u-Qiang Lu Guo-Cheng Zhang Hui Ding Zhao-Lin Shi Ru-Ying Li 
Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hi...
关键词：HIRUDIN PHARMACOLOGY Clinical application Adverse reactions 
Combination of Quercetin, Hirudin and Cinnamaldehyde Promotes Schwann Cell Differentiation and Myelination against High Glucose by Inhibiting ERK Signaling Pathway被引量：2
《Chinese Journal of Integrative Medicine》2020年第8期591-598,共8页LIU Di LIANG Xiao-chun SUN Ying WU Ya-nan ZHANG Hong 
Supported by the National Natural Science Foundation of China(No.81473639);the Youth Scientific Research Foundation of Peking Union Medical College(No.33320140118)。
Objective:To investigate the therapeutic and synergistic effects of QHC(combination of quercetin(Q),hirudin(H)and cinnamaldehyd(C))on Schwann cell differentiation and myelination against high glucose(HG)induced injury...
关键词：diabetic peripheral neuropathy extracellular signal-regulated kinase pathway Schwann cells MYELINATION Chinese medicine synergistic effect 
RGD-hirudin-based low molecular weight peptide prevents blood coagulation via subcutaneous injection被引量：3
《Acta Pharmacologica Sinica》2020年第6期753-762,共10页Ya-ran Li Yi-nong Huang Bing Zhao Meng-fang Wu Tian-yu Li Yan-ling Zhang Di Chen Min Yu Wei Mo 
This study was supported by the National Natural Science Foundation of China(NSFC 81673498);the Science and Technology Commission of Shanghai Municipality(STCSM 16431904600).
Thromboembolic disease is a common cardio-cerebral vascular disease that threatens human life and health.Thrombin not only affects the exogenous coagulation pathway,but also the endogenous pathway.Thus,it becomes one ...
关键词：RGD-hirudin thrombin inhibitor direct thrombin inhibitor peptide(DTIP) homology simulation molecular docking THROMBELASTOGRAPHY bio-layer interferometry subcutaneous injection 
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