基于新评价体系的胰腺囊性肿瘤消融有效性分析  

The efficacy of EUS-LA in the treatment of PCNs under the new evaluation system

作　　者：宁波 柴宁莉[1] 李惠凯[1] 冯秀雪[1] 杜晨[1] 李笑 张晓彬[1] 赵鑫[1,3] 令狐恩强 Ning Bo;Chai Ningli;Li Huikai;Feng Xiuxue;Du Chen;Li Xiao;Zhang Xiaobin;Zhao Xin;Linghu Enqiang(Senior Department of Gastroenterology,The First Medical Center of PLA General Hospital,Beijing 100853,China;Medical School of Chinese PLA,Beijing 100853,China;Nankai University School of Medicine,Nankai University,Tianjin 300071,China)

机构地区：[1]解放军总医院第一医学中心消化内科医学部,北京100853 [2]解放军医学院,北京100853 [3]南开大学医学院,天津300071

出　　处：《中华腔镜外科杂志（电子版）》2021年第5期293-297,共5页Chinese Journal of Laparoscopic Surgery(Electronic Edition)

摘　　要：目的对超声内镜引导下聚桂醇注射消融术(endoscopic ultrasonography-guided lauromacrogol ablation,EUS-LA)治疗胰腺囊性肿瘤(panceratic cystic neoplasms,PCNs)的有效性进行分析。方法前瞻性地纳入2015年4月至2021年7月解放军总医院第一医学中心85例行EUS-LA的PCNs患者,基于新评价体系对其中随访的75例进行有效性分析。完全消失定义为最终体积=0,接近完全消失定义为0<最终体积≤10%原始体积,显著有效为10%原始体积<最终体积≤25%原始体积,有效定义为25%原始体积<最终体积≤75%原始体积,稳定定义为75%原始体积<最终体积≤100%原始体积,进展定义为最终体积>100%原始体积。结果新方法评价体系下评价初次有效性:完全消失25例(33.3%)、接近完全消失12例(16.0%)、显著有效15例(20.0%)、有效10例(13.3%)、稳定10例(13.3%)、进展3例(4.0%);总体有效性:完全消失28例(37.3%)、接近完全消失15例(20.0%)、显著有效12例(16.0%)、有效7例(9.3%)、稳定9例(12.0%)、进展4例(5.3%)。结论在新评价体系下初次消融病变缩小有效率和总体消融病变缩小有效率均得到提高,其不仅能评价病变不同程度体积缩小所产生的效果,而且能描述病变增大所产生的进展趋势。Objective To evaluate the efficacy of endoscopic ultrasonography-guided lauromacrogol ablation(EUS-LA)in the treatment of pancreatic cystic tumors(PCNs).Methods From Apr.2015 to Jul.2021,85 patients treated with EUS-LA were enrolled in the First Medical Center of PLA General Hospital,and 75 of them were followed up for validity analysis based on the new evaluation system.The definitions are as follows,complete disappearance,final volume(FV)=0;nearly complete disappearance,0<FV≤10%original volume(OV);significantly effective,10%<FV≤25%OV;effective,25%OV<FV≤75%OV;stabilization,75%OV<FV≤100%OV;progress>100%OV.Results The initial effectiveness of the new evaluation system was as follows:complete disappearance in 25 cases(33.3%),nearly complete disappearance in 12 cases(16.0%),significantly effective in 15 cases(20.0%),effective in 10 cases(13.3%),stabilization in 10 cases(13.3%),progress in 3 cases(4.0%).The overall effectiveness of the new evaluation system was as follows:28 cases(37.3%)complete disappearance,15 cases(20.0%)nearly complete disappearance,12 cases(16.0%)significantly effective,7 cases(9.3%)effective,9 cases(12.0%)stabilization,4 cases(5.3%)progress.Conclusions Based on the new evaluation system,both the effective rate of initial and total lesion reduction were improved,which could not only evaluate the effect of different degree of lesion reduction,but also describe the progressive trend of lesion enlargement.

关 键 词：胰腺囊性肿瘤 新评价体系 超声内镜引导下聚桂醇消融术 病变缩小 有效性 

分 类 号：R73[医药卫生—肿瘤]