代谢相关脂肪性肝病患者MRI-PDFF分布特点  

Characteristics of magnetic resonance imaging proton density fat fraction in patients with metabolic associated fatty liver disease

作　　者：陆玮婷[1] 史会连[1] 陈沁磊 武建海[2] 刘绍伟[3] 乔飞[1] Lu Weiting;Shi Huilian;Chen Qinlei;Wu Jianhai;Liu Shaowei;Qiao Fei(Department of Infectious Diseases,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China;Department of Nutrition,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China;Department of Radiology,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]江苏省中医院感染科,南京210029 [2]江苏省中医院营养科,南京210029 [3]江苏省中医院放射科,南京210029

出　　处：《中华临床医师杂志（电子版）》2021年第7期503-508,共6页Chinese Journal of Clinicians(Electronic Edition)

基　　金：江苏省中医院院级课题(Y2018CX09)。

摘　　要：目的探讨代谢相关脂肪性肝病(MAFLD)患者磁共振成像评估质子密度脂肪分数(MRI-PDFF)分布特点及其与腹围、臀围、体质量指数(BMI)及肝功能的关系。方法收集2018年1月至2020年4月江苏省中医院感染科门诊超声诊断为MAFLD的患者171例,行磁共振成像3.0上腹部平扫加MRI-PDFF测定,并进行身高、体质量、腹围、臀围以及丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转移酶(GGT)水平检测。结果171例MAFLD患者肝脏MRI-PDFF平均值为(13.76±10.30)%。随着肝脏脂肪含量的增高,患者的腹围、臀围、BMI以及肝功能水平也逐渐增高,不同程度的MRI-PDFF患者中,腹围(F=4.050,P=0.008)、臀围(F=3.449,P=0.018)、BMI(F=3.552,P=0.016)及ALT(H=27.904,P<0.001)、AST(H=25.070,P<0.001)、GGT(H=24.039,P<0.001)水平均有统计学差异。相关性分析显示,MRI-PDFF与ALT(r=0.459,P<0.001)、AST(r=0.436,P<0.001)呈中度正相关,而与BMI相关性极低(r=0.149,P=0.052)。结论MRI-PDFF作为一种无创的、可定量测定肝脏脂肪含量的方法,能较为准确地反映肝脏的脂肪含量,适用于肝脏脂肪含量的动态评估及疗效监测。Objective To investigate the characteristics of magnetic resonance imaging proton density fat fraction(MRI-PDFF)in patients with metabolic associated fatty liver disease(MAFLD)and analyze the relationship of MRI-PDFF with abdominal circumference,hip circumference,body mass index(BMI),and liver function.Methods A total of 171 infectious outpatients with MAFLD at Jiangsu Province Hospital of Chinese Medicine were recruited from January 2018 to April 2020.The MRI-PDFF,height,weight,abdominal circumference,hip circumference,and serum indexes of liver function(ALT,AST,ALP,and GGT)in all patients were tested.Results The MRI-PDFF of the 171 patients was(13.79±10.32)%.As the liver fat content increased,the patients'abdominal circumference,hip circumference,BMI,and liver function levels also gradually increased.The abdominal circumference(F=4.050,P=0.008),hip circumference(F=3.449,P=0.018),BMI(F=3.552,P=0.016),ALT(H=27.904,P<0.001),AST(H=25.070,P<0.001),GGT(H=24.039,P<0.001)differed significantly among different levels of MRI-PDFF.Correlation analysis showed that liver MRI-PDFF was moderately related to ALT(r=0.459,P<0.001)and AST(r=0.436,P<0.001),but had a very low correlation with BMI(r=0.149,P=0.052).Conclusion MRIPDFF as a non-invasive and quantitative method can accurately reflect liver fat content,and is suitable for dynamic evaluation of liver fat content and monitoring of treatment effect.

关 键 词：磁共振成像 质子密度脂肪分数 代谢相关脂肪性肝病 

分 类 号：R575.5[医药卫生—消化系统]