射频消融治疗肺磨玻璃结节的临床价值  

Radiofrequency Ablation for Lung Ground-glass Nodule

作　　者：谭晓刚[1] 刘宝东[1] Xiaogang TAN;Baodong LIU(Department of Thoracic Surgery,Xuan Wu Hospital of Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院胸外科,北京100053

出　　处：《中国肺癌杂志》2021年第10期677-682,共6页Chinese Journal of Lung Cancer

基　　金：首都医科大学临床专科学院(系)开放课题(No.RG00667)资助。

摘　　要：背景与目的随着计算机断层扫描(computed tomography,CT)广泛应用于肺癌筛查,越来越多的肺磨玻璃结节(ground-glass nodule,GGN)被发现,尽早干预有利于提高肺癌患者的生存率。射频消融(radiofrequency ablation,RFA)是治疗原发性或转移性肺部恶性肿瘤的一种替代方法。本研究旨在探讨RFA治疗肺GGN的安全性和临床疗效。方法选择我院2016年6月-2021年3月收治的24例肺GGN患者,共计28枚结节,接受RFA治疗,其中男性13例,女性11例,平均年龄为(69.4±11.1)岁。接受RFA的GGN大小为(1.30±0.56)cm;消融范围为(2.50±0.63)cm;消融时间为(15.00±8.68)min。结果全部结节手术顺利,所有患者无围术期死亡,术中无严重并发症发生。中位随访时间为25个月。1例术后2个月因心梗去世。28个结节均无局部进展,局部控制率为100.0%。Kaplan-Meier分析患者1年、2年的总体生存率分别为95.8%、95.8%;肿瘤特异生存率分别为100.0%、100.0%。结论RFA是治疗肺GGN安全有效的微创技术。Background and objective With the wide application of computed tomography(CT)in the screening of early lung cancer,more and more ground glass nodules(GGNs)have been found.Early intervention is helpful to improve the survival rate of lung cancer patients.Radiofrequency ablation(RFA)is an alternative option to manage primary or metastatic lung malignancies.The purpose of this study is to review the safety and clinical efficacy for lung GGN treated by RFA.Methods From June 2016 to March 2021,24 patients with a total of 28 lung GGNs in our hospital underwent 28 sessions of RFA.There were 13 males and 11 females with an average age of(69.4±11.1)years.The size of GGN receiving RFA was(1.30±0.56)cm;The ablation range was(2.50±0.63)cm and ablation time was(15.00±8.68)min.Results The procedure of all RFAs went smoothly,no perioperative deaths occurred and no serious complications during the operation.The median follow-up was 25 months.One case died of myocardial infarction 2 months after operation.All 28 GGNs showed no evidence of local progression and the local control rate was 100.0%.Kaplan-Meier analysis showed that the 1-year and 2-year overall survival rates were 95.8%and 95.8%;the tumor specific survival rates were 100.0%and 100.0%,respectively.Conclusion RFA is a safe,effective and minimally invasive technique for the treatment of lung GGNs.

关 键 词：射频消融 肺磨玻璃结节 临床疗效 

分 类 号：R734.2[医药卫生—肿瘤]