丁苯酞联合依达拉奉治疗急性脑梗死的临床疗效及对血流指标的影响  

Clinical efficacy of butylphthalide combined with edaravone in treatment of acute cerebral infarction and its influence on blood flow index

作　　者：张圆圆 金晓倩 裴晓蕊 赵婧 范雷涛 孟秀君[3] ZHANG Yuanyuan;JIN Xiaoqian;PEI Xiaorui;ZHAO Jing;FAN Leitao;MENG Xiujun(Department of Neurology,Chaoyang Central Hospital in Liaoning Province,Chaoyang 122000,China;Department of Colorectal Anal Surgery,Chaoyang Central Hospital in Liaoning Province,Chaoyang 122000,China;No.1 of Department of Neurology,the Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China)

机构地区：[1]辽宁省朝阳市中心医院神经内科,辽宁朝阳122000 [2]辽宁省朝阳市中心医院结直肠肛门外科,辽宁朝阳122000 [3]中国医科大学附属第四医院第一神经内科,辽宁沈阳110032

出　　处：《中国现代医生》2021年第26期5-8,共4页China Modern Doctor

摘　　要：目的 探讨丁苯酞联合依达拉奉治疗急性脑梗死的临床疗效和血流指标变化。方法 回顾性分析朝阳市中心医院神经内科2016年1月至2019年6月收治的285例急性脑梗死患者,根据用药不同将其分为对照组140例和观察组145例;两组患者在给予常规基本治疗基础上,对照组给予依达拉奉注射液静点;观察组同时给予丁苯酞联合依达拉奉注射液静点。比较两组用药前和用药14 d后的治愈率、NIHSS评分和mRS评分、血流指标变化(全血黏度、全血浆黏度和血小板聚集率)。结果 观察组总有效率为89.66%,明显高于对照组的74.29%,差异有统计学意义(χ^(2)=11.450,P=0.001)。治疗14 d后两组NIHSS评分和mRS评分均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗后观察组的NIHSS评分为(7.57±1.05)分,mRS评分为(2.30±0.46)分,明显低于对照组的(9.84±1.33)分、(3.31±0.46)分,差异有统计学意义(P<0.05);治疗后两组的全血黏度、全血浆黏度和血小板聚集率较治疗前均明显降低,且观察组降低幅度均高于对照组,差异有统计学意义(P<0.05)。结论 相对于依达拉奉单独应用,丁苯酞和依达拉奉联合使用能够显著改善血液流变学,抑制血栓形成,保护神经细胞和脑组织,提高患者的治愈率。Objective To investigate the clinical efficacy of butylphthalide combined with edaravone in the treatment of acute cerebral infarction and blood flow index changes.Methods A retrospective analysis of 285 patients with acute cerebral infarction admitted to the Department of Neurology of Chaoyang Central Hospital from January 2016 to June 2019 was conducted.They were divided into the control group and the observation group according to the medication,with 140 cases in the control group and 145 cases in the observation group,respectively.In addition to the routine basic treatment,the control group were given edaravone injection intravenously,and the observation group were given butylphthalide combined with edaravone injection intravenously.The cure rate,NIHSS score,mRS score,and changes in blood flow indicators(whole blood viscosity,whole plasma viscosity,and platelet aggregation rate)were compared between the two groups before and at 14 days after treatment.Results The total effective rate in the observation group was 89.66%,which was significantly higher than that of 74.29%in the control group,with significant difference(χ^(2)=11.450,P=0.001).At 14 days after treatment,the scores of NIHSS and mRS in the two groups were significantly lower than before treatment.The scores of NIHSS and mRS in the observation group were(7.57±1.05)points and(2.30±0.46)points,which were significantly lower than those of(9.84±1.33)points and(3.31±0.46)points in the control group,with statistically significant differences(P<0.05).The blood flow indicators,including whole blood viscosity,whole plasma viscosity,and platelet aggregation rate,were significantly lower than those before treatment,and the decreases of blood flow indicators in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion Compared with edaravone alone,the combined use of butylphthalide and edaravone can significantly improve blood rheology,inhibit thrombosis,protect nerve cells and brain tissu

关 键 词：丁苯酞 依达拉奉 急性脑梗死 血液动力学指标 

分 类 号：R743.32[医药卫生—神经病学与精神病学]