COX-2和NCOA5在甲状腺乳头状癌淋巴结转移灶中的表达及应用  

Expression and Application of COX-2 and NCoA5 in Lymph Node Metastasis of Papillary Thyroid Carcinoma

作　　者：李军[1] 王宏坤[2] 万海玉 王博[1] 郑绘霞[2] Li Jun;Wang Hongkun;Wan Haiyu(Shanxi Medical University,the First Hospital of Shanxi Medical University,Shanxi 030000,China)

机构地区：[1]山西医科大学,太原030000 [2]山西医科大学第一医院,太原030000

出　　处：《医学研究杂志》2021年第10期133-137,21,共6页Journal of Medical Research

摘　　要：目的探究环氧合酶-2(COX-2)和核受体辅激活子5(NCOA5)在PTC淋巴结转移灶中的表达及应用。方法收集117例手术切除的甲状腺乳头状癌患者的临床、影像及病理学资料,用免疫组化检测PTC及癌旁组织中NCOA5、COX-2表达,并分析其与临床病理特征及其与淋巴结转移之间的关系。结果高分期、中低分化的肿瘤、肿瘤侵犯包膜与PTC淋巴结转移密切相关,NCOA5蛋白的阴性表达和COX-2蛋白的阳性表达情况在PTC高分期、中低分化、侵犯包膜、颈部有淋巴结转移灶、颈部超声周边血流异常信号中与低分期、高分化、未侵犯包膜、颈部无淋巴结转移灶、颈部超声周边血流无异常信号比较,差异有统计学意义。结论COX-2的阳性表达和NCOA5的阴性表达模式与PTC的临床病理特征及颈部淋巴结转移密切相关,可作为PTC临床诊疗及评估颈部淋巴结转移的重要依据。Objective To investigate the expression and application of COX-2 and NCOA5 in lymph node metastasis of PTC.Methods The clinical,imaging and pathological data of 117 patients with PTC were collected.Immunohistochemical staining was used to detect the expression of NCOA5 and COX-2 in PTC tissues and adjacent normal tissues,and the relationship between the expression and clinicopathological characteristics and lymph node metastasis was analyzed.Results High stage,medium and low differentiated tumor,tumor invasion capsule were closely related to lymph node metastasis of papillary thyroid carcinoma.NCOA5 protein expression of negative and positive expression of COX-2 protein in PTC high stage,low differentiation,invasion of coated with lymph node metastases,neck and neck ultrasound and clinical staging in peripheral blood flow abnormal signal low stage,high differentiation,not infringe capsular,neck without lymph node metastases,neck ultrasound peripheral blood flow abnormalities.Compared with signals,the difference was statistically significant.Conclusion The positive expression of COX-2 and the negative expression pattern of NCOA5 are closely related to the clinicopathological characteristics of PTC and cervical lymph node metastasis,which can be used as an important basis for the clinical diagnosis and treatment of PTC and the evaluation of cervical lymph node metastasis.

关 键 词：甲状腺乳头状癌 环氧合酶-2 核受体辅激活子5 淋巴结转移 

分 类 号：R736.1[医药卫生—肿瘤]