肝衰竭与肠道屏障损害关系的研究进展  

Research advances in the association between liver failure and intestinal barrier injury

作　　者：肖玲燕 邢阿雯 谭善忠[2] XIAO Lingyan;XING Awen;TAN Shanzhong(Department of Critical Care Medicine,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210003,China;Department of Integrated Traditional Chinese and Western Medicine for Liver Diseases,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210003,China;School of Medicine&Holistic Integrative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学附属南京医院重症医学科,南京210003 [2]南京中医药大学附属南京医院中西医结合肝病,南京210003 [3]南京中医药大学医学院·整合医学院,南京210023

出　　处：《临床肝胆病杂志》2021年第11期2710-2714,共5页Journal of Clinical Hepatology

基　　金：江苏省中医药领军人才项目(SLJ0216)。

摘　　要：肝衰竭与肠道屏障损害尤其是肠道微生态失衡相互影响,互为因果。肝衰竭时肠道屏障包括化学物质、机械、免疫和微生物屏障发生损害,同时由于肠道微生态失调、细菌内毒素增加及胆汁酸代谢异常等影响肝细胞再生,增加并发症的产生,可加重肝衰竭病情。治疗肝衰竭应同时重视肠道屏障功能的维护,针对肠道屏障损害尤其是微生态紊乱的治疗是比较有前景的治疗方法。Liver failure and intestinal barrier injury,especially intestinal microflora imbalance,interacts as both the cause and effect of each other.Intestinal barrier injury is observed during liver failure,including the injuries of chemical,mechanical,immune,and microbial barriers,and meanwhile,gut dysbiosis,increased bacterial endotoxins,and abnormal bile acid metabolism may affect hepatocyte regeneration,increase complications,and aggravate the conditions of liver failure.The maintenance of intestinal barrier function should be taken seriously in the treatment of liver failure,and the treatment targeting intestinal barrier injury,especially microecological disturbance,is a promising method.

关 键 词：肝功能衰竭 肠黏膜屏障 胃肠道微生物组 治疗学 

分 类 号：R575.3[医药卫生—消化系统]