四君子汤加味治疗功能性消化不良的系统评价  

Systematic review of modified Sijunzi decoction in treatment of functional dyspepsia

作　　者：冷雪峰[1] 车思阳 白光[1] Leng Xuefeng;Che Siyang;Bai Guang(Hospital Affiliated to Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学附属医院,沈阳110032

出　　处：《国际医药卫生导报》2021年第21期3366-3369,共4页International Medicine and Health Guidance News

基　　金：沈阳市科技计划项目(18-013-0-82)。

摘　　要：目的系统评价四君子汤治疗功能性消化不良的临床疗效。方法计算机检索中国知网、万方、维普、PubMed、The Cochrane Library数据库,搜索四君子汤相关中医复方治疗功能性消化不良的随机对照试验,检索时间范围是各数据库建库到2021年1月10日,两名研究者根据纳入标准各自进行文献检索、筛选、数据提取,其中观察指标包括:总体有效率、症状积分、胃半排空时间,评估所纳入文献的偏倚风险,应用RevMan 5.4进行定量分析。结果共纳入文献11篇,858例患者。meta结果显示:在总有效率方面,四君子汤优于常规西药组(治疗组/对照组=445/413,RR=1.25,95%CI:1.17~1.32,P<00001),症状积分方面存在优势(治疗组/对照组=106/106,MD=-3.47,95%CI:-3.77~-3.17,P<00001),胃半排空时间上两组疗效相当(治疗组/对照组=63/50,MD=-0.16,95%CI:-2.21~1.88,P=0.88)。结论四君子汤复方治疗功能性消化不良的临床疗效显著,和单纯西药组比较,疗效存在优势,但仍需更多高质量的研究予以证明。Objective To systematically evaluate the clinical efficacy of Sijunzi decoction in the treatment of functional dyspepsia.Methods Databases,including CNKI,Wanfang,VIP,PubMed,and The Cochrane Library were searched to collect the random control trials related to modified Sijunzi decoction in the treatment of functional dyspepsia from the establishment of each database to January 10,2021.Two researchers screened the literatures and extracted the data.The observation indicators included overall effective rate,symptom score,and gastric half-emptying time.The risk of bias of the included literatures was assessed.The data were quantitatively analyzed by the Revman 5.4 statistical software.Results A total of 11 articles with 858 patients were included.The meta results showed that compared with the conventional western medicine group,the Sijunzi decoction group had advantages in overall effective rate[the treatment group/the control group=445/413,RR=1.25,95%CI(1.17,1.32),P<0.00001]and symptom score[the treatment group/the control group=106/106,MD=-3.47,95%CI(-3.77,-3.17),P<0.00001],and had the same curative effect in gastric half-emptying time[the treatment group/the control group=63/50,MD=-0.16,95%CI(-2.21,1.88),P<0.88].Conclusion Compared with the simple western medicine group,Sijunzi decoction has definite curative effect in treating functional dyspepsia and certain advantages,but more high-quality studies are needed to prove it.

关 键 词：四君子汤 功能性消化不良 随机对照试验 META分析 

分 类 号：R57[医药卫生—消化系统]