非小细胞肺癌组织DSG3与Ki-67表达相关性及预后意义  

Correlation between DSG3 and Ki-67 expressions in non-small cell lung cancer tissue and its prognostic significance

作　　者：赵甜甜 滕圣敏 满其荣 王祥阁[1] 张新东[1] Zhao Tiantian;Teng Shengmin;Man Qirong;Wang Xiangge;Zhang Xindong(Department of Pathology,Tengzhou Central People's Hospital,Tengzhou 277500,China;Department of Oncology,Tengzhou Central People's Hospital,Tengzhou 277500,China)

机构地区：[1]济宁医学院附属滕州市中心人民医院病理科,山东277500 [2]济宁医学院附属滕州市中心人民医院肿瘤科,山东277500

出　　处：《国际医药卫生导报》2021年第21期3377-3381,共5页International Medicine and Health Guidance News

摘　　要：目的分析非小细胞肺癌(NSCLC)组织中细胞桥粒芯蛋白3(DSG3)与Ki-67表达的相关性,探讨DSG3的表达状态对NSCLC患者预后的影响。方法收集滕州市中心人民医院2015年7月至2019年12月期间行外科手术切除并经术后常规病理确诊的NSCLC标本72例,用免疫组织化学方法(IHC)检测石蜡标本中DSG3和Ki-67的表达状态,分析DSG3的表达与Ki-67增殖指数的相关性;收集72例患者的临床病理资料,包括年龄、性别、肿瘤长径、病理类型、肿瘤分化程度和是否有淋巴结转移,并定期随访,分析DSG3的表达与这些临床病理特征的关系和对患者预后的影响。结果72例患者中,男51例,女21例,中位年龄65岁。肺鳞状细胞癌30例,肺腺癌42例;DSG3阳性29例,DSG3阴性43例。肺鳞状细胞癌组Ki-67增殖指数为(35.00±14.02)%,肺腺癌组Ki-67增殖指数为(28.81±13.83)%,两组Ki-67值差异无统计学意义(P=0.067);DSG3阳性组Ki-67值为(27.07±12.21)%,DSG3阴性组Ki-67值为(34.30±14.74)%,DSG3阳性组明显低于DSG3阴性组(P=0.032)。统计学结果显示DSG3表达与肿瘤的病理类型、分化程度和是否有淋巴结转移相关(χ^(2)=33.734,P<0.001;χ^(2)=6.847,P=0.033;χ^(2)=5.855,P=0.016),与其余临床病理特征均无明显相关性(均P>0.05);Kaplan-Meier法分析结果显示患者的总生存期在DSG3表达阳性组与阴性组之间差异无统计学意义(P=0.204)。结论NSCLC组织中DSG3的表达状态与Ki-67增殖指数有相关性,DSG3的表达状态对NSCLC患者的预后有一定影响。Objective To investigate the relationship between DSG3 and Ki-67 expressions in patients with non-small cell lung cancer(NSCLC)and its effect on prognosis.Methods A total of 72 patients with NSCLC,which were surgically removed and diagnosed by routine pathological section examination in Tengzhou Central People's Hospital from July 2015 to December 2019,were collected.The expressions of DSG3 and Ki-67 in these patients were detected by immunohistochemistry,and the relationship between DSG3 expression and Ki-67 proliferation index was analyzed.The clinicopathologic factors associated with tumor prognosis,including age,gender,tumor diameter,pathological type,tumor differentiation,and lymph node metastasis,were collected.They were followed up regularly.The relationship between DSG3 expression and these clinicopathological data was statistically analyzed.Kaplan-Meier method was used to evaluate the effect of DSG3 expression on the patients'prognosis.Results Among the 72 patients,there were 51 males and 21 females,with a median age of 65.Thirty patients had lung squamous cell carcinoma,and 42 had lung adenocarcinoma.Twenty-nine patients were positive in DSG3,and 43 negative.The Ki-67 proliferation index was(35.00±14.02)%in the lung squamous cell carcinoma group,and was(28.81±13.83)%in the lung adenocarcinoma group(P=0.067).The Ki-67 proliferation index was(27.07±12.21)%in the DSG3-positive group,and was(34.30±14.74)%in the DSG3-negative group(P=0.032).The expression of DSG3 was correlated with pathological type,tumor differentiation status,and lymph node metastasis(χ^(2)=33.734,P<0.001;χ^(2)=6.847,P=0.033;χ^(2)=5.855,P=0.016),but not with other clinicopathologic features(all P>0.05).Kaplan-Meier analysis showed that there was no statistical difference in the total survival time between the DSG3 positive and negative groups(P=0.204).Conclusion The expression of DSG3 in NSCLC is correlated with Ki-67 proliferation index,and has some prognostic value in NSCLC patients.

关 键 词：非小细胞肺癌 DSG3 KI-67 预后 

分 类 号：R734.2[医药卫生—肿瘤]